{"id":"W4409281449","doi":"10.1016/j.biopsych.2025.02.476","title":"239. Exploring the Neurobiology of Irritability and Suicidality in Major Depressive Disorder: A Pilot fMRI Study","year":2025,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Stress Responses and Cortisol","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; University of Toronto","funders":"","keywords":"Irritability; Psychology; Neuroscience; Major depressive disorder; Psychiatry; Clinical psychology; Anxiety; Amygdala","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002431118,0.0001814672,0.0001590116,0.00009681509,0.0003376896,0.0003576221,0.0002915887,0.0004761901,0.005532089],"category_scores_gemma":[0.0003001275,0.0001318975,0.0001751138,0.00006401665,0.000295288,0.0002633337,0.000178745,0.000378936,0.0007546128],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001572011,"about_ca_system_score_gemma":0.0002963671,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001858062,"about_ca_topic_score_gemma":0.00296523,"domain_scores_codex":[0.9999746,0.00000567551,0.000001626166,0.000006143564,0.000004262004,0.000007665069],"domain_scores_gemma":[0.9999114,0.00003231913,0.000007936391,0.000006558869,0.00001192886,0.00002980281],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.02350006,0.003273423,0.05578294,0.0009305633,0.0003689449,0.00783035,0.001790275,0.000574778,0.7502058,0.001963156,0.007976661,0.145803],"study_design_scores_gemma":[0.005308524,0.02380577,0.8393974,0.0002648423,0.0007077418,0.009491224,0.002598524,0.002562682,0.08603366,0.005072158,0.02465913,0.00009828889],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898364,0.0009353986,0.0009934142,0.001055115,0.0001483615,0.0002101563,0.0003695113,0.00002204843,0.00642971],"genre_scores_gemma":[0.9876546,0.001512803,0.002399183,0.001615988,0.000273561,0.0002600751,0.0003437568,0.00002349776,0.005916556],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005532089,"threshold_uncertainty_score":0.01850665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.077301485493093,"score_gpt":0.3204293242711227,"score_spread":0.2431278387780297,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}