{"id":"W4409283701","doi":"10.1038/s41586-025-08878-3","title":"Multimodal cell maps as a foundation for structural and functional genomics","year":2025,"lang":"en","type":"article","venue":"Nature","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Human Genome Research Institute; National Institutes of Health","keywords":"Computational biology; Genome; Biology; Computer science; Functional genomics; Genomics; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001024727,0.0007039386,0.0007366469,0.001955196,0.0005249513,0.001810258,0.001355932,0.0006690408,0.005295225],"category_scores_gemma":[0.001601355,0.0004699742,0.0006150863,0.001249367,0.00116082,0.001673199,0.002290088,0.001519211,0.001866986],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001092552,"about_ca_system_score_gemma":0.0005777244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001588028,"about_ca_topic_score_gemma":0.001263432,"domain_scores_codex":[0.9997161,0.000066956,0.0000148252,0.00009164779,0.00008554857,0.0000249089],"domain_scores_gemma":[0.9990042,0.000279102,0.00009302793,0.0003815557,0.0001432558,0.0000989522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002667193,0.000141469,0.002944903,0.0005689634,0.0001485164,0.0003927143,0.0004915413,0.09413772,0.3635336,0.3419112,0.01189906,0.1835635],"study_design_scores_gemma":[0.00004127287,0.0001393221,0.004356774,0.0001238903,0.00006567832,0.0002290939,0.0002478442,0.3537818,0.08607627,0.4245307,0.1303075,0.00009978272],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.02458266,0.0008294704,0.9569449,0.0006661087,0.00008693161,0.00005803289,0.003863388,0.006326316,0.006642114],"genre_scores_gemma":[0.2390727,0.001819737,0.745551,0.0002947153,0.0001061513,0.0002604809,0.00872603,0.001711061,0.002458086],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.005295225,"threshold_uncertainty_score":0.01771426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004850718280243598,"score_gpt":0.2402202302949011,"score_spread":0.2353695120146575,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}