{"id":"W4409285683","doi":"10.1056/nejmc2412616","title":"Plozasiran for Managing Persistent Chylomicronemia and Pancreatitis Risk","year":2025,"lang":"en","type":"letter","venue":"New England Journal of Medicine","topic":"Lipid metabolism and disorders","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Robarts Clinical Trials","funders":"","keywords":"Pancreatitis; Medicine; Intensive care medicine; Internal medicine; Pediatrics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003562813,0.0004717242,0.0006943263,0.0005736855,0.001386512,0.001301699,0.0005053135,0.008553113,0.004924879],"category_scores_gemma":[0.004114422,0.0002667089,0.000800384,0.0004329442,0.0007990535,0.001204663,0.000632578,0.008887369,0.001659724],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00153767,"about_ca_system_score_gemma":0.001271921,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001094172,"about_ca_topic_score_gemma":0.002153779,"domain_scores_codex":[0.9997185,0.00007154196,0.0000468144,0.00003159165,0.00006250632,0.00006913101],"domain_scores_gemma":[0.9992961,0.000288178,0.00009379811,0.00002199692,0.00004901388,0.0002510534],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001069281,0.0002726969,0.01624939,0.0003631039,0.0001475211,0.5048231,0.000335436,0.0006364415,0.001936804,0.010128,0.3697408,0.09429746],"study_design_scores_gemma":[0.001205117,0.0007050157,0.01247578,0.001118837,0.0002062704,0.6017122,0.0005713877,0.002855882,0.001309388,0.0200919,0.3576499,0.00009820577],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.03723172,0.02328597,0.0009858506,0.8629677,0.01546236,0.00007707667,0.000124502,0.0001388173,0.05972603],"genre_scores_gemma":[0.3975518,0.01780512,0.00299898,0.4565026,0.09344464,0.0001267051,0.0001904147,0.00008374359,0.0312961],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.008553113,"threshold_uncertainty_score":0.01647544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01328406138718248,"score_gpt":0.2524734563192277,"score_spread":0.2391893949320453,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}