{"id":"W4409285702","doi":"10.1056/nejmoa2407934","title":"Assessment of a Polygenic Risk Score in Screening for Prostate Cancer","year":2025,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Prostate Cancer Diagnosis and Treatment","field":"Medicine","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"European Research Council; Cancer Research UK; Royal Marsden Cancer Charity; Peacock Trust; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research","keywords":"Polygenic risk score; Prostate cancer; Oncology; Internal medicine; Medicine; Cancer; Biology; Genetics; Gene; Genotype; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006064709,0.000664157,0.0004210385,0.002501528,0.0004504525,0.0008288642,0.0004949539,0.0007059547,0.001980545],"category_scores_gemma":[0.01334902,0.0001553034,0.001021801,0.002131711,0.0005167961,0.0005541825,0.001163049,0.0007588425,0.0002758574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004160784,"about_ca_system_score_gemma":0.0005044131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003669813,"about_ca_topic_score_gemma":0.004598272,"domain_scores_codex":[0.9955314,0.002993962,0.0002718556,0.0004278765,0.0005587362,0.0002162425],"domain_scores_gemma":[0.9921077,0.003581482,0.002536183,0.00060078,0.000565788,0.0006080891],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001147604,0.000049987,0.9926779,0.00001735364,0.0002968269,0.00005277595,0.0000582502,0.0005955865,0.0001712333,0.0001641679,0.0001936268,0.005607523],"study_design_scores_gemma":[0.00001082322,0.0002460399,0.9939645,0.00001530769,0.0001518488,0.0002744874,0.00006061258,0.004237947,0.00007320804,0.0006602997,0.000290494,0.00001426291],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924843,0.0004934746,0.003926069,0.0002540347,0.00002257391,0.00009370591,0.0007443257,0.00003073977,0.001950702],"genre_scores_gemma":[0.9974058,0.00008056112,0.001942759,0.00002541584,0.00001445054,0.00003912021,0.0003689305,0.000002606799,0.000120289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006064709,"threshold_uncertainty_score":0.03207368,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02776535463105723,"score_gpt":0.3608361983802976,"score_spread":0.3330708437492404,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}