{"id":"W4409286918","doi":"10.1038/s41375-025-02593-8","title":"DEK::NUP214 acts as an XPO1-dependent transcriptional activator of essential leukemia genes","year":2025,"lang":"en","type":"article","venue":"Leukemia","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont; Institute for Research in Immunology and Cancer; Centre Hospitalier Universitaire Sainte-Justine","funders":"Directorate for Biological Sciences; Barts Health NHS Trust; University College London Hospitals NHS Foundation Trust; Université de Montréal; Semmelweis Egyetem; Institut National de la Santé et de la Recherche Médicale; Cancer Research UK; Kay Kendall Leukaemia Fund; Österreichischen Akademie der Wissenschaften; Helsingin Yliopisto; Francis Crick Institute; Genome Canada; European Hematology Association; Centre hospitalier universitaire Sainte-Justine; University College London; Helsinki Institute of Life Science, Helsingin Yliopisto; Queen Mary University of London; Barts Charity; Veterinärmedizinische Universität Wien; Cancer Research Institute","keywords":"Biology; Transcriptome; Fusion gene; Gene; Activator (genetics); Fusion protein; Leukemia; Hox gene; Myeloid leukemia; Cancer research; Chromosomal translocation; Promoter; Genetics; Transcription factor; Computational biology; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000522422,0.0004030664,0.0007156993,0.0005245483,0.0001806071,0.00005578646,0.000553151,0.0004669607,0.00114942],"category_scores_gemma":[0.0002644877,0.0003764837,0.000266111,0.0006791072,0.0003217248,0.0003742354,0.0001586378,0.0008717062,0.000176307],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.004286824,"about_ca_system_score_gemma":0.008882672,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001010368,"about_ca_topic_score_gemma":0.0001015874,"domain_scores_codex":[0.9964845,0.0001692298,0.0006883666,0.0007591954,0.001092969,0.0008057505],"domain_scores_gemma":[0.9978891,0.0001795205,0.0001547923,0.0009381972,0.0003738081,0.0004645629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002346828,0.0002568601,0.004737602,0.0005176947,0.0005115033,0.0002504609,0.0004621234,0.0001720726,0.9597931,0.01255171,0.005223097,0.01317696],"study_design_scores_gemma":[0.009286523,0.0006633225,0.05075493,0.0003788021,0.0004205617,0.0002353302,0.0006752204,0.00174967,0.8990924,0.001620729,0.0345837,0.0005388102],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9788748,0.0005027315,0.001241531,0.001044274,0.0005147297,0.0007368009,0.00004911218,0.0001688275,0.01686721],"genre_scores_gemma":[0.983789,0.0002330396,0.001278494,0.001014037,0.0005726961,0.00007816956,0.0001708126,0.00006869412,0.01279508],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06070068,"threshold_uncertainty_score":0.9998687,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01697448296931518,"score_gpt":0.3151619623183538,"score_spread":0.2981874793490386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}