{"id":"W4409286918","doi":"10.1038/s41375-025-02593-8","title":"DEK::NUP214 acts as an XPO1-dependent transcriptional activator of essential leukemia genes","year":2025,"lang":"en","type":"article","venue":"Leukemia","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont; Institute for Research in Immunology and Cancer; Centre Hospitalier Universitaire Sainte-Justine","funders":"Directorate for Biological Sciences; Barts Health NHS Trust; University College London Hospitals NHS Foundation Trust; Université de Montréal; Semmelweis Egyetem; Institut National de la Santé et de la Recherche Médicale; Cancer Research UK; Kay Kendall Leukaemia Fund; Österreichischen Akademie der Wissenschaften; Helsingin Yliopisto; Francis Crick Institute; Genome Canada; European Hematology Association; Centre hospitalier universitaire Sainte-Justine; University College London; Helsinki Institute of Life Science, Helsingin Yliopisto; Queen Mary University of London; Barts Charity; Veterinärmedizinische Universität Wien; Cancer Research Institute","keywords":"Biology; Transcriptome; Fusion gene; Gene; Activator (genetics); Fusion protein; Leukemia; Hox gene; Myeloid leukemia; Cancer research; Chromosomal translocation; Promoter; Genetics; Transcription factor; Computational biology; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001412368,0.0003624413,0.0003911602,0.0002387101,0.0001769421,0.0004114588,0.0002183455,0.0002284635,0.001089595],"category_scores_gemma":[0.0001547625,0.0001475253,0.0002441085,0.0001967731,0.000238258,0.0001579276,0.0004808998,0.0003388567,0.0005245536],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004258028,"about_ca_system_score_gemma":0.0001744933,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000225782,"about_ca_topic_score_gemma":0.0007190997,"domain_scores_codex":[0.9998116,0.00002167285,0.00001559409,0.00005694483,0.0000618178,0.0000323771],"domain_scores_gemma":[0.9999307,0.000009707675,0.00002583342,0.000009672171,0.000006778019,0.00001722992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000143414,0.00001840544,0.0008355152,0.00004345765,0.000009249597,0.0001391487,0.000008032296,0.0002459809,0.9961255,0.00006059584,0.00007092774,0.002299679],"study_design_scores_gemma":[0.00003340056,0.0002343556,0.01566666,0.000008000568,0.00002174212,0.001339043,0.00002592387,0.001196872,0.9725296,0.00009726064,0.008838193,0.000008823887],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934145,0.001953925,0.001613421,0.0001242362,0.00002113536,0.0000269694,0.0008939224,0.000134361,0.001817512],"genre_scores_gemma":[0.9940491,0.0009980623,0.001460356,0.00005766725,0.00000530457,0.00002079255,0.001368626,0.00002728462,0.002012809],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001089595,"threshold_uncertainty_score":0.003645062,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01697448296931518,"score_gpt":0.3151619623183538,"score_spread":0.2981874793490386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}