{"id":"W4409287938","doi":"10.20944/preprints202504.0557.v1","title":"Using UV–Vis Titration to Elucidate Novel EGCG-Induced Stabilization of the c-MYC G-Quadruplex","year":2025,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"","keywords":"G-quadruplex; Titration; Chemistry; Molecular biology; Cancer research; Biochemistry; Biology; DNA; Inorganic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003615539,0.0006599378,0.0003560037,0.0002667489,0.0002161661,0.0002069623,0.0005309727,0.0006806692,0.001153178],"category_scores_gemma":[0.0004293669,0.0002484681,0.0002952491,0.0003299768,0.000296995,0.0002819123,0.0002011974,0.0007862756,0.0002605784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003643128,"about_ca_system_score_gemma":0.0001907513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006735111,"about_ca_topic_score_gemma":0.0008131407,"domain_scores_codex":[0.9997199,0.00005498456,0.00001957378,0.00008537952,0.00007880766,0.00004135147],"domain_scores_gemma":[0.9997769,0.00009629239,0.0000491227,0.00001478992,0.00004130384,0.00002155897],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004935946,0.00003082685,0.00004441298,0.00004472616,0.00000571798,0.00001008901,0.00002593795,0.0001003243,0.9991428,0.00002531476,0.00001153727,0.0005089435],"study_design_scores_gemma":[0.000007236036,0.0001522454,0.0003931395,0.000003020943,0.000006044464,0.00001519273,0.000009688679,0.001172354,0.9979463,0.0000218151,0.0002676879,0.000005273177],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880379,0.0009609156,0.009435807,0.00009482195,0.00003638534,0.00006971698,0.0003187439,0.0001699851,0.0008757078],"genre_scores_gemma":[0.9803835,0.0009720254,0.01639348,0.0001202265,0.00001229182,0.0001537161,0.000465162,0.00004093227,0.001458746],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001153178,"threshold_uncertainty_score":0.003857732,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1209421607563276,"score_gpt":0.3618652896760632,"score_spread":0.2409231289197356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}