{"id":"W4409287940","doi":"10.20944/preprints202504.0582.v1","title":"SMARCB1 Deficiency as a Driver of the Hallmarks of Cancer in Rhabdoid Tumours: Novel Insights into Dysregulated Energy Metabolism, Emerging Targets, and Ongoing Clinical Trials","year":2025,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"","keywords":"Clinical trial; Cancer; Energy metabolism; Medicine; Cancer research; Bioinformatics; Biology; Neuroscience; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001321718,0.0006457646,0.001641312,0.0005573499,0.0001589889,0.001113662,0.0005236339,0.0007826829,0.002058008],"category_scores_gemma":[0.0006683927,0.0001980076,0.0007879929,0.0005485663,0.0005393447,0.0007786178,0.0004380258,0.001981205,0.0005542796],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005447743,"about_ca_system_score_gemma":0.0007277954,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003025142,"about_ca_topic_score_gemma":0.0009096481,"domain_scores_codex":[0.9998135,0.00004861714,0.0000217197,0.00004074837,0.00004419854,0.00003129003],"domain_scores_gemma":[0.99958,0.0002068741,0.00007068129,0.00001689215,0.00007133721,0.00005424089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003205007,0.0005015922,0.00303791,0.01485338,0.0008296357,0.0008541776,0.0001254435,0.001139039,0.04602202,0.006587279,0.01308688,0.9097575],"study_design_scores_gemma":[0.002030456,0.007127064,0.01661309,0.01053469,0.003781193,0.007388638,0.0004752214,0.002482818,0.03117301,0.01582097,0.9023978,0.0001749956],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003985856,0.9934644,0.0005312375,0.0008388421,0.0001373018,0.00001999825,0.00005576636,0.00002729118,0.0009393613],"genre_scores_gemma":[0.03355134,0.9625909,0.001161553,0.0009435004,0.0003012455,0.00007691191,0.0003400799,0.00001295106,0.001021605],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002058008,"threshold_uncertainty_score":0.006990016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07722502905943186,"score_gpt":0.4033537400495921,"score_spread":0.3261287109901602,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}