{"id":"W4409290127","doi":"10.1091/mbc.e25-03-0119","title":"A morphology and secretome map of pyroptosis","year":2025,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"HEC Montréal","funders":"National Science Foundation","keywords":"Pyroptosis; Inflammasome; Cell biology; Programmed cell death; Biology; Apoptosis; Caspase; Caspase 1; Cell; Secretion; Organelle; Inflammation; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000834058,0.000183425,0.0001811276,0.0005465879,0.0001358001,0.0003928366,0.0001139468,0.0002274596,0.001133222],"category_scores_gemma":[0.0001943241,0.0001096861,0.0002391153,0.0003494666,0.0001715141,0.0003677857,0.0002134162,0.00034826,0.0002182475],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002635497,"about_ca_system_score_gemma":0.00012963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004759044,"about_ca_topic_score_gemma":0.0005528063,"domain_scores_codex":[0.9999429,0.000006433359,0.000002602149,0.00001957362,0.00001721641,0.00001128937],"domain_scores_gemma":[0.9999059,0.00002389885,0.00002493933,0.00001429524,0.00001722295,0.00001377918],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001784465,0.00002349287,0.005088225,0.00006808659,0.00001738568,0.0001356188,0.00005800551,0.002982342,0.9784182,0.0006858281,0.000141661,0.01220268],"study_design_scores_gemma":[0.00002335945,0.0003597907,0.218466,0.00002594602,0.00006213339,0.001241193,0.0002030673,0.1084606,0.6598121,0.005277977,0.006025841,0.00004196829],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9485353,0.00058186,0.04571718,0.0001223094,0.00001226221,0.00004764792,0.00202257,0.000399929,0.002561063],"genre_scores_gemma":[0.9759405,0.0005545951,0.02076359,0.00005843249,0.00001110981,0.00005093638,0.00134472,0.00003400195,0.00124223],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001133222,"threshold_uncertainty_score":0.003791034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002382958633252886,"score_gpt":0.2163784190324279,"score_spread":0.213995460399175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}