{"id":"W4409295276","doi":"10.1016/j.biopsych.2025.02.182","title":"Cross-Trial Generalization of Behavioral and Neuroimaging Markers for Treatment Response in Major Depression: Evidence From EMBARC and CANBIND Studies","year":2025,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Treatment of Major Depression","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"","keywords":"Neuroimaging; Depression (economics); Generalization; Psychology; Neuroscience; Clinical psychology; Philosophy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch","metaepi_broad"],"consensus_categories":[],"category_scores_codex":[0.03977571,0.00128161,0.004962167,0.0005515001,0.001171805,0.001513637,0.001491299,0.002893758,0.003564636],"category_scores_gemma":[0.07186186,0.000801606,0.003249549,0.001015591,0.002010074,0.0030409,0.001692589,0.003047311,0.001097852],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001277703,"about_ca_system_score_gemma":0.001055632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002384074,"about_ca_topic_score_gemma":0.002542524,"domain_scores_codex":[0.9730681,0.01763756,0.002423419,0.003442761,0.002804302,0.0006238021],"domain_scores_gemma":[0.9300845,0.03631964,0.01047678,0.01613707,0.004954265,0.002027764],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.752094,0.008328708,0.06774183,0.00277926,0.05260083,0.00009763831,0.00114802,0.001766927,0.003380882,0.0008014992,0.004302158,0.1049584],"study_design_scores_gemma":[0.08953859,0.121467,0.7385737,0.001334537,0.02821517,0.0003670481,0.0006290742,0.002809682,0.003808871,0.003993338,0.008936248,0.0003266484],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9604591,0.02280181,0.003615911,0.001088807,0.001160465,0.002029523,0.001582451,0.0003104657,0.006951576],"genre_scores_gemma":[0.9912442,0.00228266,0.001370678,0.001030352,0.0002485823,0.001023583,0.001428103,0.00007671378,0.001295145],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9950379,"threshold_uncertainty_score":0.2103566,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09715036377724957,"score_gpt":0.4270285664930323,"score_spread":0.3298782027157828,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}