{"id":"W4409296282","doi":"10.1101/2025.04.04.647210","title":"Proteostasis control via HSP90α sustains YAP activity to drive aggressive behaviours in cancer-associated fibroblasts","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Agencia Estatal de Investigación; Medical Research Council; Banco Bilbao Vizcaya Argentaria; Boehringer Ingelheim Fonds; Wellcome Trust; European Association for Cancer Research","keywords":"Proteostasis; Hsp90; Cancer; Cell biology; Psychology; Medicine; Biology; Internal medicine; Heat shock protein; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009248672,0.0002039278,0.0001349372,0.000150481,0.0001412196,0.0002634093,0.00008248002,0.0001411827,0.001299939],"category_scores_gemma":[0.00005749326,0.0000891535,0.0001320823,0.0001093065,0.0001458058,0.0001245518,0.00020444,0.0003216971,0.0005396393],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001968747,"about_ca_system_score_gemma":0.0001136148,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003554279,"about_ca_topic_score_gemma":0.0004910048,"domain_scores_codex":[0.9999549,0.000004955985,0.000002675367,0.00001018378,0.00001348142,0.00001383199],"domain_scores_gemma":[0.9999614,0.000002655096,0.00001203397,0.000006245069,0.000005222256,0.00001238929],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004176263,0.000007067158,0.0003881449,0.00001648244,0.000003192969,0.00005687729,0.000007378942,0.00007724143,0.9979175,0.0001494894,0.0001144338,0.001220429],"study_design_scores_gemma":[0.00001967863,0.0001028794,0.02146092,0.000008532885,0.00000928075,0.0005321828,0.00005415027,0.002630119,0.9696624,0.0003755291,0.005138762,0.000005618071],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882154,0.001630679,0.006338009,0.0002447676,0.00003925102,0.0000150569,0.0007624555,0.000258723,0.002495695],"genre_scores_gemma":[0.99584,0.0004693817,0.0009251532,0.00002991086,0.000009263689,0.000008068514,0.0003892521,0.00002257992,0.002306467],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001299939,"threshold_uncertainty_score":0.004348755,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008970608605683664,"score_gpt":0.2474977944525193,"score_spread":0.2385271858468356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}