{"id":"W4409299954","doi":"10.1016/j.jid.2025.03.021","title":"Selective USP7 Inhibition Synergizes with MEK1/2 Inhibitor to Enhance Immune Responses and Potentiate Anti–PD-1 Therapy in NRAS-Mutant Melanoma","year":2025,"lang":"en","type":"article","venue":"Journal of Investigative Dermatology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"National Institute on Aging; Natural Sciences and Engineering Research Council of Canada; Alberta Innovates; School of Medicine, Southern Illinois University; National Institutes of Health; Thomas Jefferson University","keywords":"Melanoma; Neuroblastoma RAS viral oncogene homolog; Cancer research; Mutant; Immune system; Medicine; Chemistry; Immunology; Cancer; Internal medicine; KRAS","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001780664,0.0004467278,0.0005038696,0.0003328365,0.0002000726,0.0003115415,0.0002535383,0.0002460524,0.002022265],"category_scores_gemma":[0.0001075632,0.0001601897,0.0004104344,0.0001841412,0.0002062568,0.0002519529,0.0001617912,0.0009105435,0.0004491505],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002752342,"about_ca_system_score_gemma":0.0003432345,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005449135,"about_ca_topic_score_gemma":0.002199072,"domain_scores_codex":[0.9998716,0.00002187669,0.00001134572,0.00001611473,0.00002611676,0.0000529347],"domain_scores_gemma":[0.9999477,0.000009623405,0.000007463531,0.000006781044,0.000004186566,0.00002424562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005882575,0.001883292,0.0006970816,0.0002252167,0.0001102811,0.0002528767,0.00004024067,0.001076187,0.9556179,0.0005304574,0.001934483,0.03174941],"study_design_scores_gemma":[0.001404369,0.01508981,0.01148969,0.00002208841,0.0002420935,0.001249172,0.00007095686,0.003819147,0.955722,0.0002214804,0.01063683,0.0000324086],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919696,0.002685012,0.0008392903,0.0001990763,0.0001670052,0.00008786636,0.0004414005,0.0001799342,0.003430791],"genre_scores_gemma":[0.9963436,0.0009873069,0.0007694843,0.00006049505,0.00002815479,0.00005246887,0.0003739305,0.00001415457,0.001370456],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002022265,"threshold_uncertainty_score":0.006765127,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008313673016199178,"score_gpt":0.2599467860875276,"score_spread":0.2516331130713285,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}