{"id":"W4409300339","doi":"10.1016/j.phrs.2025.107714","title":"Multidisciplinary consensus on the diagnosis and management of patients with atypical Hemolytic Uremic Syndrome (complement-mediated TMA): Recommendations from Italian scientific societies, patient associations and regulators","year":2025,"lang":"en","type":"review","venue":"Pharmacological Research","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Hospital Foundation","funders":"European Rare Kidney Disease Reference Network; Ministero dell’Istruzione, dell’Università e della Ricerca; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico; Alexion Pharmaceuticals","keywords":"Multidisciplinary approach; Complement (music); Consensus conference; Medicine; Intensive care medicine; Complement system; Atypical hemolytic uremic syndrome; Immunology; Political science; Internal medicine; Law; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1097268,0.001357516,0.001656222,0.005316556,0.003327328,0.004918157,0.004647761,0.008047464,0.002446],"category_scores_gemma":[0.1101437,0.0008209114,0.003839347,0.003246147,0.003406515,0.003736785,0.008097781,0.008371867,0.001538774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006552934,"about_ca_system_score_gemma":0.03571281,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007396401,"about_ca_topic_score_gemma":0.007811512,"domain_scores_codex":[0.9080576,0.05569508,0.01805408,0.002179228,0.0123068,0.003707207],"domain_scores_gemma":[0.8707651,0.04430594,0.01118593,0.003108411,0.05923731,0.01139728],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002260743,0.0004289138,0.01075246,0.01470734,0.0004860277,0.001689129,0.01898924,0.001850618,0.002012703,0.01761395,0.4038362,0.5274073],"study_design_scores_gemma":[0.0004491053,0.0004137022,0.02091229,0.07166106,0.000826102,0.003328026,0.02608761,0.003356378,0.0012447,0.04020693,0.8310697,0.0004444295],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"review","genre_scores_codex":[0.01214381,0.07230604,0.03269517,0.8385573,0.01775336,0.002778294,0.0005644682,0.0004044822,0.02279705],"genre_scores_gemma":[0.2726064,0.1378077,0.3697184,0.186107,0.01050323,0.009389201,0.003843163,0.0003087476,0.009716216],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.1097268,"threshold_uncertainty_score":0.5802976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1700567714745367,"score_gpt":0.4282193492234789,"score_spread":0.2581625777489422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}