{"id":"W4409300742","doi":"10.7150/thno.107963","title":"Targeted radioligand therapy: physics and biology, internal dosimetry and other practical aspects during <sup>177</sup>Lu/<sup>225</sup>Ac treatment in neuroendocrine tumors and metastatic prostate cancer","year":2025,"lang":"en","type":"review","venue":"Theranostics","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Dosimetry; Prostate cancer; Radiobiology; Context (archaeology); Radiation therapy; Radionuclide therapy; Radioligand; Cancer research; External beam radiotherapy; Medicine; Cancer; Oncology; Nuclear medicine; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000393082,0.000426493,0.0005644084,0.0006169883,0.0001464897,0.0006909687,0.0004184659,0.0005846387,0.001215578],"category_scores_gemma":[0.0002626004,0.0001455911,0.000290483,0.0009332151,0.000329532,0.0006677197,0.0002717747,0.0004448731,0.0005843916],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005744798,"about_ca_system_score_gemma":0.0006047261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007749537,"about_ca_topic_score_gemma":0.001239439,"domain_scores_codex":[0.9998417,0.00003665961,0.00001428511,0.00002879994,0.00006085537,0.00001763954],"domain_scores_gemma":[0.9999057,0.00003447638,0.00002003851,0.000004016425,0.00003018476,0.000005618156],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002299603,0.00006429973,0.001060857,0.01751422,0.0001258845,0.0009220024,0.0003692669,0.002121669,0.1214574,0.008663592,0.01210102,0.8353699],"study_design_scores_gemma":[0.00001209543,0.0005100095,0.0044035,0.0009292309,0.0001928402,0.004294455,0.0001895321,0.0007946664,0.06304187,0.002133548,0.9234505,0.00004773858],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003864642,0.9904035,0.002311131,0.0002895795,0.0001865724,0.000008613373,0.00002996773,0.00002392268,0.002882061],"genre_scores_gemma":[0.0267593,0.9641948,0.002643322,0.0005108988,0.0004268092,0.00002846981,0.00008909097,0.00002024009,0.005326965],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001215578,"threshold_uncertainty_score":0.004168212,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06560468514494809,"score_gpt":0.4065024644640319,"score_spread":0.3408977793190838,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}