{"id":"W4409300742","doi":"10.7150/thno.107963","title":"Targeted radioligand therapy: physics and biology, internal dosimetry and other practical aspects during <sup>177</sup>Lu/<sup>225</sup>Ac treatment in neuroendocrine tumors and metastatic prostate cancer","year":2025,"lang":"en","type":"review","venue":"Theranostics","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Dosimetry; Prostate cancer; Radiobiology; Context (archaeology); Radiation therapy; Radionuclide therapy; Radioligand; Cancer research; External beam radiotherapy; Medicine; Cancer; Oncology; Nuclear medicine; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001127977,0.0006883184,0.00172072,0.0001586618,0.00008712924,0.00006095043,0.000105489,0.0001213466,0.00002632822],"category_scores_gemma":[0.0001590711,0.0004965671,0.0001395439,0.0004259789,0.0004040836,0.00006107574,0.00008394353,0.0007214885,0.000001594069],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001532502,"about_ca_system_score_gemma":0.0003070405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006564225,"about_ca_topic_score_gemma":0.000001925558,"domain_scores_codex":[0.9977839,0.000210372,0.0006399914,0.0007424218,0.0001347112,0.0004886158],"domain_scores_gemma":[0.9981946,0.0009104921,0.0002094057,0.0003570001,0.00004021577,0.0002883072],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001957955,0.002349439,0.007991727,0.04434434,0.005432529,0.001573349,0.002247224,0.000156201,0.004559367,0.001709025,0.000170912,0.9275079],"study_design_scores_gemma":[0.03248434,0.002238953,0.001044684,0.03294102,0.0148679,0.008091164,0.0005889233,0.008177573,0.02212152,0.002188976,0.8717287,0.003526242],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1230262,0.873938,0.00003028313,0.000432136,0.00002684615,0.001979244,0.0003498591,0.000106116,0.0001114126],"genre_scores_gemma":[0.03999304,0.958371,0.0002491697,0.0002664603,0.0002612724,0.0003499059,0.00007010291,0.0001291121,0.0003099263],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9239817,"threshold_uncertainty_score":0.9997486,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06560468514494809,"score_gpt":0.4065024644640319,"score_spread":0.3408977793190838,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}