{"id":"W4409311797","doi":"10.1016/j.biopha.2025.118044","title":"Cannabinoid Receptor 2 (CB2R) as potential target for the pharmacological treatment of neurodegenerative diseases","year":2025,"lang":"en","type":"review","venue":"Biomedicine & Pharmacotherapy","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lakehead University","funders":"Università degli Studi di Milano-Bicocca","keywords":"Cannabinoid receptor; Endocannabinoid system; Cannabinoid; Medicine; Neuroscience; Pharmacology; Receptor; Internal medicine; Biology; Antagonist","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002396067,0.0005293568,0.0007988974,0.001548555,0.0002419127,0.0006008235,0.000540534,0.00064801,0.005582323],"category_scores_gemma":[0.0002811264,0.0001385769,0.0004225927,0.001111238,0.0002216025,0.0005780262,0.0003979503,0.001234618,0.001829748],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004673334,"about_ca_system_score_gemma":0.0009640189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001439271,"about_ca_topic_score_gemma":0.003307875,"domain_scores_codex":[0.9999007,0.00001580157,0.000012637,0.00001828674,0.00004053034,0.00001208937],"domain_scores_gemma":[0.9999136,0.00003229165,0.00001327778,0.000002832659,0.00002702531,0.00001104801],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001133309,0.0001111757,0.0001671501,0.02426879,0.0001266405,0.0003731321,0.000082462,0.0004262985,0.007412788,0.004987527,0.02993869,0.9319919],"study_design_scores_gemma":[0.00002328573,0.000128694,0.0008781069,0.002761375,0.0001708299,0.001274584,0.00005611778,0.0001030898,0.001087387,0.001568234,0.9919299,0.00001839467],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002890367,0.9971692,0.0001463616,0.0002299758,0.0001828444,0.000007059758,0.00003241019,0.00001083017,0.001932263],"genre_scores_gemma":[0.001576077,0.996538,0.0002295216,0.0001930568,0.0001268339,0.000007509199,0.00004539406,0.000001687781,0.001282005],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005582323,"threshold_uncertainty_score":0.01867479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0452629839062588,"score_gpt":0.4290330966770352,"score_spread":0.3837701127707764,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}