{"id":"W4409314212","doi":"10.1186/s12890-025-03634-9","title":"Cannabis smoking is associated with persistent epigenome-wide disruptions despite smoking cessation","year":2025,"lang":"en","type":"article","venue":"BMC Pulmonary Medicine","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; St. Paul's Hospital; Queen's University; University of British Columbia","funders":"","keywords":"Cannabis; Epigenome; DNA methylation; Medicine; Epigenetics; Smoking cessation; Effects of cannabis; Cannabis Dependence; Cohort; Psychiatry; Internal medicine; Bioinformatics; Genetics; Gene; Biology; Cannabidiol; Gene expression; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002397374,0.0001861837,0.0003900731,0.0006012729,0.0005866438,0.0005173272,0.0003311924,0.0002927657,0.001292785],"category_scores_gemma":[0.001230967,0.0001777809,0.000396616,0.001035502,0.0003512298,0.0001345481,0.0003913241,0.000394456,0.00009209834],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007776983,"about_ca_system_score_gemma":0.001113839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.1282333,"about_ca_topic_score_gemma":0.1880239,"domain_scores_codex":[0.999696,0.00002628336,0.00001437266,0.0001111725,0.00007031874,0.0000818325],"domain_scores_gemma":[0.9993235,0.0001240786,0.0002405896,0.00006952,0.00012862,0.0001136354],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000698337,0.00002081016,0.9628325,0.0000744428,0.0004156039,0.0002381765,0.0002401416,0.0002353482,0.02725152,0.0001301088,0.0002639946,0.007598982],"study_design_scores_gemma":[0.00000262726,0.00001818213,0.9986785,0.000004719868,0.00006059849,0.0001132947,0.00005959094,0.000182718,0.0005819789,0.00006732559,0.000227287,0.000003098502],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960003,0.001306659,0.0005284302,0.0001178149,0.000007269834,0.00001342764,0.001438,0.00001961712,0.0005683991],"genre_scores_gemma":[0.9985718,0.0002780853,0.0002235488,0.00003583681,0.000003455692,0.000006660938,0.000600091,0.000004748034,0.0002757975],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1282333,"threshold_uncertainty_score":0.2549738,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01916158769692958,"score_gpt":0.2735830798772698,"score_spread":0.2544214921803403,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}