{"id":"W4409317760","doi":"10.1164/rccm.202411-2231oc","title":"Long-Term Safety and Efficacy of Elexacaftor/Tezacaftor/Ivacaftor in Adults and Adolescents with Cystic Fibrosis and at Least One <i>F508del</i> Allele: A Phase 3 Open-Label Extension Study","year":2025,"lang":"en","type":"article","venue":"American Journal of Respiratory and Critical Care Medicine","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia; University of Toronto; St. Michael's Hospital","funders":"Vertex Pharmaceuticals","keywords":"Ivacaftor; Medicine; Cystic fibrosis; Allele; Pediatrics; Internal medicine; Genetics; Cystic fibrosis transmembrane conductance regulator","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00237178,0.0006876571,0.00110846,0.0002508379,0.0004069032,0.0005988309,0.000395506,0.001023926,0.001969274],"category_scores_gemma":[0.001212822,0.000293188,0.001287029,0.0001947179,0.0005082602,0.00072735,0.0002877747,0.00189655,0.0004089118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003630511,"about_ca_system_score_gemma":0.0006851031,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006053867,"about_ca_topic_score_gemma":0.001095142,"domain_scores_codex":[0.9993312,0.0003206838,0.00004663032,0.00009696496,0.0001048614,0.00009970787],"domain_scores_gemma":[0.9987019,0.0002063779,0.0004301563,0.00009248628,0.0001347668,0.0004342256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7640879,0.07130984,0.03511313,0.0005842487,0.001312648,0.0002575053,0.0004690881,0.0006943347,0.04580945,0.0001040926,0.001411375,0.07884643],"study_design_scores_gemma":[0.2329366,0.6780671,0.08008862,0.00007041876,0.0008743,0.0002958929,0.0001499267,0.0008613299,0.004962538,0.0001035258,0.00155283,0.0000369796],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983291,0.0004740502,0.0001397321,0.00004874132,0.00002035182,0.0003843746,0.0002920547,0.00001519446,0.0002964378],"genre_scores_gemma":[0.9975108,0.0002998893,0.0004493983,0.0001747333,0.00005497614,0.0005763835,0.0004283788,0.000005253667,0.000500185],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00237178,"threshold_uncertainty_score":0.01254326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02135781709449103,"score_gpt":0.3676488845494458,"score_spread":0.3462910674549547,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}