{"id":"W4409317896","doi":"10.1101/2025.04.04.647097","title":"NALCN/Cch1 channelosome subunits originated in early eukaryotes and are fully conserved in animals, fungi, and apusomonads","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Protist diversity and phylogeny","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"","keywords":"Biology; Protein subunit; Phylogenetic tree; Context (archaeology); Evolutionary biology; Phylogenetics; Genetics; Clade; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000745025,0.0001803653,0.00017734,0.0005017041,0.00031994,0.0003522186,0.0001100952,0.0002189129,0.001643416],"category_scores_gemma":[0.000189039,0.00009114211,0.0001925074,0.0004090636,0.0002047014,0.0003137522,0.0003736225,0.0002207126,0.0005560974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002350845,"about_ca_system_score_gemma":0.0002236474,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006565924,"about_ca_topic_score_gemma":0.001365062,"domain_scores_codex":[0.9999372,0.000003509987,0.000003596203,0.00002909863,0.00001297506,0.0000136326],"domain_scores_gemma":[0.9998717,0.00001756754,0.00005032342,0.00001774901,0.00001496745,0.00002761035],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002694066,0.00001153767,0.02503572,0.0001615653,0.00002488501,0.0004552056,0.0001376256,0.0001925867,0.9601228,0.0004350957,0.0001048661,0.01304875],"study_design_scores_gemma":[0.00003051351,0.0001641632,0.745866,0.00008164857,0.00009991254,0.003690266,0.0004952161,0.00274572,0.2147092,0.0009730564,0.03110713,0.00003699367],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921876,0.001473097,0.003429162,0.00003897594,0.00001528331,0.00001364162,0.001091935,0.00009922253,0.001651128],"genre_scores_gemma":[0.9932622,0.0004871948,0.003050448,0.00003673969,0.000009612012,0.00001032196,0.001990824,0.00002344902,0.001129295],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001643416,"threshold_uncertainty_score":0.005497813,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01108424832668129,"score_gpt":0.2066152811864155,"score_spread":0.1955310328597342,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}