{"id":"W4409318045","doi":"10.1200/po-24-00742","title":"<i>BRCA1/2</i> and Other Predisposition Genes in High-Risk Hormone Receptor+/Human Epidermal Growth Factor Receptor 2– Breast Cancer Treated With Endocrine Therapy With or Without Palbociclib: A Secondary PENELOPE-B Study Analysis","year":2025,"lang":"en","type":"article","venue":"JCO Precision Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"","keywords":"Palbociclib; Oncology; Breast cancer; Medicine; Internal medicine; Hazard ratio; Cancer; Hormone receptor; Placebo; Metastatic breast cancer; Confidence interval; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001436736,0.0004490577,0.0008341523,0.0002264838,0.0002200585,0.0007054633,0.0003812514,0.0003192903,0.004125994],"category_scores_gemma":[0.001105164,0.0001681239,0.001209906,0.0002414624,0.0002729139,0.0002861597,0.0002790164,0.0007199222,0.0002510762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003740275,"about_ca_system_score_gemma":0.000621269,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005247146,"about_ca_topic_score_gemma":0.0009014949,"domain_scores_codex":[0.9993568,0.0003024627,0.00004506868,0.0001757361,0.00005518103,0.00006478048],"domain_scores_gemma":[0.9992279,0.0002072591,0.0002014876,0.0001109744,0.00005985246,0.0001925092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.6479583,0.007811293,0.2225033,0.002137344,0.01078936,0.0007804028,0.0001590719,0.001660729,0.0188136,0.0006160027,0.004835838,0.08193485],"study_design_scores_gemma":[0.1761362,0.186966,0.5837938,0.0003879965,0.01716,0.00302921,0.0002183013,0.004705041,0.01248702,0.001179063,0.01386252,0.00007478907],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936736,0.002168931,0.0003544699,0.000107298,0.00004026491,0.0005130662,0.001464645,0.00001312425,0.001664663],"genre_scores_gemma":[0.9969727,0.0004112973,0.0002292869,0.0001397503,0.00008832181,0.0001991018,0.001274516,0.000004634671,0.0006804463],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004125994,"threshold_uncertainty_score":0.01380277,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01564005323123783,"score_gpt":0.3257295918809627,"score_spread":0.3100895386497248,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}