{"id":"W4409318045","doi":"10.1200/po-24-00742","title":"<i>BRCA1/2</i> and Other Predisposition Genes in High-Risk Hormone Receptor+/Human Epidermal Growth Factor Receptor 2– Breast Cancer Treated With Endocrine Therapy With or Without Palbociclib: A Secondary PENELOPE-B Study Analysis","year":2025,"lang":"en","type":"article","venue":"JCO Precision Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"","keywords":"Palbociclib; Oncology; Breast cancer; Medicine; Internal medicine; Hazard ratio; Cancer; Hormone receptor; Placebo; Metastatic breast cancer; Confidence interval; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003380465,0.0005889432,0.00163582,0.0008425975,0.00023082,0.00004506583,0.0002149093,0.00022703,0.001461564],"category_scores_gemma":[0.000026811,0.0003618561,0.0001021303,0.001727124,0.0003033245,0.0003151669,0.0000961054,0.000586172,0.000005676984],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000670257,"about_ca_system_score_gemma":0.0004970844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005029733,"about_ca_topic_score_gemma":0.0113006,"domain_scores_codex":[0.9964958,0.0006342471,0.0007651875,0.001113253,0.0004306043,0.0005608685],"domain_scores_gemma":[0.997987,0.0003765592,0.0004659975,0.0005759876,0.0003775604,0.0002168463],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.04384626,0.001410153,0.7721886,0.00003063925,0.002553681,0.00006613446,0.001297969,0.00005678269,0.008162376,0.000007251791,0.0001290583,0.1702511],"study_design_scores_gemma":[0.03223605,0.008115486,0.9486342,0.0001813952,0.001093622,0.0001027776,0.0012268,0.00006098855,0.003206155,0.00003348097,0.00465283,0.0004562339],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928305,0.002038903,0.0006103645,0.001172935,0.00009108437,0.002497783,0.0003999043,0.0001666881,0.0001918578],"genre_scores_gemma":[0.9924271,0.001645709,0.002707801,0.0007655887,0.0001791251,0.000993514,0.00009226718,0.00009702437,0.001091935],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1764456,"threshold_uncertainty_score":0.9998834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01564005323123783,"score_gpt":0.3257295918809627,"score_spread":0.3100895386497248,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}