{"id":"W4409323802","doi":"10.1002/anie.202502367","title":"A Ketone‐Accepting Pictet–Spenglerase for the Asymmetric Construction of 1,1‐Disubstituted Tetrahydro‐ß‐carboline Alkaloids","year":2025,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Phytochemical compounds biological activities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Ministry of Education, Culture, Sports, Science and Technology; Japan Society for the Promotion of Science; Natural Sciences and Engineering Research Council of Canada; Japan Science and Technology Agency; New Energy and Industrial Technology Development Organization; National Institutes of Health","keywords":"Stereoselectivity; Ketone; Pictet–Spengler reaction; Chemistry; Stereochemistry; Tryptophan; Substrate (aquarium); Natural product; Biosynthesis; Alkaloid; Combinatorial chemistry; Amino acid; Organic chemistry; Enzyme; Catalysis; Biochemistry; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001486729,0.0001281029,0.0001366556,0.00008448673,0.00008380461,0.00002495979,0.000261261,0.0001375742,0.00002980448],"category_scores_gemma":[0.0007837534,0.0001022253,0.0001395748,0.0001909246,0.0001890168,0.00001407675,0.00008856101,0.0001065453,8.773355e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000474655,"about_ca_system_score_gemma":0.00004864235,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001698185,"about_ca_topic_score_gemma":0.000005975661,"domain_scores_codex":[0.999175,0.00001622469,0.0002678953,0.0002543818,0.000145307,0.0001412483],"domain_scores_gemma":[0.9991673,0.0002074707,0.0001467036,0.0001634676,0.0002873106,0.00002778107],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002150544,0.00009003478,0.0006011443,0.00002486957,0.0001523634,2.748367e-7,0.00000896168,0.00002614459,0.9916483,0.0005767022,0.003413087,0.003243024],"study_design_scores_gemma":[0.000657004,0.00006682389,0.0009732348,0.00003189379,0.00003388366,0.000005202752,0.00006120739,0.0002159502,0.9795389,0.002102767,0.01620965,0.0001035228],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8926394,0.0008245623,0.08844779,0.001712681,0.002460239,0.0005804424,0.0003839832,0.00004970928,0.01290117],"genre_scores_gemma":[0.996207,0.0001462422,0.001121072,0.0002821042,0.001042997,0.0001104397,0.0008862404,0.000007775281,0.0001961197],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1035676,"threshold_uncertainty_score":0.4168625,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01261274886747654,"score_gpt":0.276416651209782,"score_spread":0.2638039023423054,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}