{"id":"W4409323802","doi":"10.1002/anie.202502367","title":"A Ketone‐Accepting Pictet–Spenglerase for the Asymmetric Construction of 1,1‐Disubstituted Tetrahydro‐ß‐carboline Alkaloids","year":2025,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Phytochemical compounds biological activities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Ministry of Education, Culture, Sports, Science and Technology; Japan Society for the Promotion of Science; Natural Sciences and Engineering Research Council of Canada; Japan Science and Technology Agency; New Energy and Industrial Technology Development Organization; National Institutes of Health","keywords":"Stereoselectivity; Ketone; Pictet–Spengler reaction; Chemistry; Stereochemistry; Tryptophan; Substrate (aquarium); Natural product; Biosynthesis; Alkaloid; Combinatorial chemistry; Amino acid; Organic chemistry; Enzyme; Catalysis; Biochemistry; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002846959,0.0005096447,0.0002381349,0.000278793,0.0001496721,0.000331004,0.0003615894,0.0005215433,0.0006869373],"category_scores_gemma":[0.0002646163,0.0002039272,0.0002681628,0.0003922468,0.0002921141,0.0004961489,0.0004264586,0.0006702681,0.000658909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003602463,"about_ca_system_score_gemma":0.0003762387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004258062,"about_ca_topic_score_gemma":0.0006864023,"domain_scores_codex":[0.9997891,0.00004033964,0.00001984971,0.00005434612,0.00005846323,0.00003787604],"domain_scores_gemma":[0.999909,0.00001283816,0.00002853569,0.00001760194,0.00001028213,0.00002179232],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004299184,0.00005588806,0.0001561638,0.0001170114,0.000009660731,0.0001680414,0.00005160216,0.0003828341,0.9883783,0.0007813005,0.0001737824,0.009682467],"study_design_scores_gemma":[0.00001154553,0.0001928438,0.0005108745,0.000006392822,0.00001128914,0.0003456071,0.00001297051,0.001394902,0.9938508,0.00008457674,0.003561897,0.00001630709],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8715115,0.005661792,0.1081616,0.0003718457,0.0001517589,0.000342254,0.0007528914,0.0006012674,0.01244499],"genre_scores_gemma":[0.9519522,0.002581168,0.04013825,0.00007119435,0.0000149105,0.00008904516,0.0006445586,0.00005110664,0.004457652],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006869373,"threshold_uncertainty_score":0.002613783,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01261274886747654,"score_gpt":0.276416651209782,"score_spread":0.2638039023423054,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}