{"id":"W4409324133","doi":"10.1182/blood.2024027742","title":"An unbiased genomewide screen uncovers 7 genes that drive hematopoietic stem cell fate from mouse embryonic stem cells","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Biology; Stem cell; Embryonic stem cell; Embryoid body; Cell biology; Haematopoiesis; Induced pluripotent stem cell; Progenitor cell; Hemangioblast; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002563357,0.0004848694,0.0002922119,0.000605819,0.0002150775,0.0003090573,0.0002650493,0.0003046574,0.001065855],"category_scores_gemma":[0.0001395539,0.0002024556,0.0003751054,0.0002698808,0.0002458252,0.00006975966,0.0002718362,0.0004202746,0.0003783337],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000220713,"about_ca_system_score_gemma":0.0003654223,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004383712,"about_ca_topic_score_gemma":0.0017311,"domain_scores_codex":[0.9997118,0.0000320385,0.00002450628,0.00007687573,0.0001095079,0.00004516991],"domain_scores_gemma":[0.9998093,0.0000617144,0.00005845795,0.00002134209,0.00001734911,0.00003186249],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00003178071,0.00001103973,0.000475646,0.00001706537,0.000007007277,0.0000645536,0.000005480623,0.00005552172,0.9982881,0.00004294778,0.0000327377,0.0009681507],"study_design_scores_gemma":[0.00001362012,0.0001672359,0.01436665,0.000006289019,0.00007124418,0.0004163262,0.00001971556,0.001258673,0.9814817,0.00004726698,0.002142804,0.000008506851],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9809534,0.0006769613,0.01306818,0.00009048848,0.00002150799,0.00008669844,0.003059131,0.0004242912,0.001619354],"genre_scores_gemma":[0.9728631,0.0006821119,0.016517,0.0001682058,0.00001052417,0.0001184331,0.006031399,0.0001301951,0.003478925],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001065855,"threshold_uncertainty_score":0.003565609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01248668390771574,"score_gpt":0.2381705851884441,"score_spread":0.2256839012807283,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}