{"id":"W4409325573","doi":"10.1371/journal.pbio.3002499","title":"Modulation of NMDA receptor signaling and zinc chelation prevent seizure-like events in a zebrafish model of SLC13A5 epilepsy","year":2025,"lang":"en","type":"article","venue":"PLoS Biology","topic":"Zebrafish Biomedical Research Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; Alberta Children's Hospital; University of Calgary","funders":"","keywords":"Biology; NMDA receptor; Glutamatergic; Zebrafish; Neuroscience; Epilepsy; Mutant; Cell biology; Glutamate receptor; Receptor; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002419081,0.0007766152,0.0006208157,0.0005250586,0.0003555086,0.0002961516,0.0005804678,0.0008721914,0.002364162],"category_scores_gemma":[0.0001803255,0.0003282029,0.0006723278,0.0001897183,0.0005506853,0.0004208495,0.0003730911,0.001312973,0.0004955041],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009627715,"about_ca_system_score_gemma":0.0008686177,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006767206,"about_ca_topic_score_gemma":0.01535665,"domain_scores_codex":[0.9996915,0.00002448114,0.00004653565,0.00006172378,0.00009345219,0.00008237969],"domain_scores_gemma":[0.9998226,0.00001329799,0.00005414406,0.00001184023,0.00002399837,0.00007427201],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002479907,0.000072658,0.0001645589,0.00008091251,0.00001334034,0.0002044142,0.00004273271,0.0001098238,0.9973705,0.0002185461,0.0002005171,0.001274032],"study_design_scores_gemma":[0.0001894826,0.001893153,0.004833443,0.00003999968,0.00009212732,0.0004459686,0.0001339522,0.002471259,0.9852812,0.0001752494,0.0044151,0.00002916426],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848385,0.001542109,0.006310339,0.0007379641,0.0001905206,0.0002299462,0.002167396,0.0006381993,0.003344984],"genre_scores_gemma":[0.9832181,0.001339519,0.004929545,0.000230704,0.00001244999,0.0003828585,0.001162013,0.00009673026,0.008628055],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006767206,"threshold_uncertainty_score":0.01345563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01698033479101241,"score_gpt":0.2918376440246915,"score_spread":0.2748573092336791,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}