{"id":"W4409325573","doi":"10.1371/journal.pbio.3002499","title":"Modulation of NMDA receptor signaling and zinc chelation prevent seizure-like events in a zebrafish model of SLC13A5 epilepsy","year":2025,"lang":"en","type":"article","venue":"PLoS Biology","topic":"Zebrafish Biomedical Research Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; Alberta Children's Hospital; University of Calgary","funders":"","keywords":"Biology; NMDA receptor; Glutamatergic; Zebrafish; Neuroscience; Epilepsy; Mutant; Cell biology; Glutamate receptor; Receptor; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002819942,0.00009434793,0.0001921259,0.0001338723,0.00002375774,0.000001657948,0.0001463509,0.0002291336,0.00001271669],"category_scores_gemma":[0.0003124764,0.00009110386,0.00004216467,0.0001944023,0.0001369029,0.000004615572,0.0001415477,0.00009348136,0.000001137087],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002127218,"about_ca_system_score_gemma":0.0001117234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002991495,"about_ca_topic_score_gemma":0.00002428086,"domain_scores_codex":[0.9989728,0.0001103079,0.0003549322,0.0002963087,0.00009217243,0.0001734188],"domain_scores_gemma":[0.9994537,0.00005239317,0.0001201003,0.0002219857,0.0001094489,0.0000423627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007761077,0.0001972774,0.01163064,0.00006392968,0.00005095737,2.227951e-8,0.0000263883,0.0002781135,0.9846771,0.0007093026,0.00006732858,0.002221336],"study_design_scores_gemma":[0.001036357,0.0002683003,0.0176724,0.0001079939,0.00001786374,3.238354e-7,0.00002788624,0.03184478,0.9397073,0.008509096,0.0006587127,0.000149018],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844264,0.0002103441,0.01438208,0.0003237627,0.0000239484,0.0004045903,0.00005498381,0.000005490024,0.0001684436],"genre_scores_gemma":[0.9974737,0.000135053,0.001784446,0.00007141802,0.00001819258,0.00008616676,0.0003042407,0.000007702771,0.0001190372],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04496982,"threshold_uncertainty_score":0.3715108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01698033479101241,"score_gpt":0.2918376440246915,"score_spread":0.2748573092336791,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}