{"id":"W4409329279","doi":"10.1016/j.neuron.2025.03.019","title":"Fibril fuzzy coat is important for α-synuclein pathological transmission activity","year":2025,"lang":"en","type":"article","venue":"Neuron","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Shanghai Advanced Research Institute, Chinese Academy of Sciences; Chinese Academy of Sciences, Shanghai Branch; Science and Technology Commission of Shanghai Municipality; Chinese Academy of Sciences; Key Technologies Research and Development Program; National Natural Science Foundation of China; National Key Research and Development Program of China; Canadian Anesthesiologists' Society; Shanghai Key Basic Research Program; Natural Science Foundation of Shanghai","keywords":"Pathological; Coat; Neuroscience; Fibril; Transmission (telecommunications); Fuzzy logic; Biophysics; Chemistry; Cell biology; Biology; Computer science; Artificial intelligence; Pathology; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000321005,0.0004052072,0.0002712568,0.0004196461,0.000764701,0.0006106989,0.0002240098,0.0008257228,0.002507696],"category_scores_gemma":[0.0004050981,0.0002268166,0.0004325612,0.00009684851,0.0003707015,0.0006064354,0.0003895214,0.0008009002,0.0004290258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003830073,"about_ca_system_score_gemma":0.0002260969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001164498,"about_ca_topic_score_gemma":0.0009463888,"domain_scores_codex":[0.9997818,0.00003009387,0.0000179131,0.00004936202,0.00007079736,0.00005006291],"domain_scores_gemma":[0.9995988,0.00003378425,0.00009739058,0.00002794593,0.0001202658,0.0001218492],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003743082,0.00005205582,0.001886059,0.00009217392,0.0000455398,0.0005892864,0.00006461977,0.00004090396,0.9932079,0.0009686907,0.0002571202,0.002421406],"study_design_scores_gemma":[0.00008477675,0.0007067452,0.09429833,0.00007167747,0.0002058621,0.007599452,0.0003750231,0.003737238,0.8803073,0.002438741,0.01012611,0.00004863827],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9811096,0.005967834,0.006574757,0.0005503509,0.0002519098,0.00005674166,0.0002287306,0.0001513851,0.005108525],"genre_scores_gemma":[0.9926,0.0007886565,0.00283976,0.0001135516,0.00003854856,0.00001394183,0.0001699539,0.00002952496,0.003406091],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002507696,"threshold_uncertainty_score":0.008389056,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02448205605058575,"score_gpt":0.3013266236293409,"score_spread":0.2768445675787551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}