{"id":"W4409329618","doi":"10.1016/j.ard.2025.02.012","title":"Certolizumab pegol to prevent adverse pregnancy outcomes in patients with antiphospholipid syndrome and lupus anticoagulant (IMPACT): results of a prospective, single-arm, open-label, phase 2 trial","year":2025,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sinai Health System","funders":"National Center for Advancing Translational Sciences; National Institute of Arthritis and Musculoskeletal and Skin Diseases; UCB US; Morris and Alma Schapiro Fund; UCB; University of Utah; National Institutes of Health; Lupus Foundation of America","keywords":"Medicine; Certolizumab pegol; Antiphospholipid syndrome; Lupus anticoagulant; Open label; Adverse effect; Pregnancy; Internal medicine; Thrombosis; Rheumatoid arthritis; Adalimumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002166166,0.00170331,0.002102084,0.0004084638,0.0003572629,0.001269106,0.0006982081,0.001538543,0.003816169],"category_scores_gemma":[0.002825605,0.0005071657,0.001903106,0.0004221324,0.001079006,0.001218992,0.0003896066,0.002801068,0.0005602794],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006084788,"about_ca_system_score_gemma":0.0009392721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006348822,"about_ca_topic_score_gemma":0.001020793,"domain_scores_codex":[0.9993312,0.000336042,0.00003773981,0.0001140921,0.00006926535,0.0001116591],"domain_scores_gemma":[0.9988245,0.0004581857,0.0002803589,0.00009150757,0.00005057443,0.0002946917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9344426,0.006150797,0.003759289,0.0008633892,0.002668469,0.0001464512,0.0001036284,0.0007668728,0.002040171,0.0002446061,0.001552584,0.0472611],"study_design_scores_gemma":[0.9552906,0.03607017,0.005803929,0.00005362916,0.001069099,0.0001134215,0.0000361407,0.0004118006,0.0002629938,0.0002406811,0.0006298714,0.00001769578],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9798185,0.01305812,0.0005492193,0.001388317,0.0003382258,0.001192443,0.000995224,0.000100239,0.002559575],"genre_scores_gemma":[0.9854819,0.006250834,0.001274276,0.00186788,0.0005600022,0.001202424,0.001567184,0.00002337944,0.001772112],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003816169,"threshold_uncertainty_score":0.0127663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0484876954714769,"score_gpt":0.3745565106117787,"score_spread":0.3260688151403018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}