{"id":"W4409332322","doi":"10.3310/nihropenres.13905.1","title":"Effectiveness of mucoactives (carbocisteine and hypertonic saline) in addition to usual airway clearance management with usual airway clearance management alone in acute respiratory failure (MARCH): study protocol for a multi-centre 2x2 factorial, randomised, controlled, open-label, Phase 3, pragmatic, clinical and cost-effectiveness trial with internal pilot","year":2025,"lang":"en","type":"article","venue":"NIHR Open Research","topic":"Respiratory Support and Mechanisms","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Health Technology Assessment Programme; Queen's University Belfast; National Institute for Health and Care Research; Intensive Care Society; Queen's University; Department of Health and Social Care","keywords":"Hypertonic saline; Airway; Medicine; Airway management; Respiratory system; Respiratory failure; Saline; Anesthesia; Intensive care medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01383084,0.004864465,0.005651641,0.001518627,0.001492281,0.002810702,0.002827591,0.006042279,0.02783499],"category_scores_gemma":[0.0151881,0.001941146,0.005285181,0.001179199,0.003716022,0.002956562,0.001791265,0.004417961,0.004120627],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003380363,"about_ca_system_score_gemma":0.005423879,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001405415,"about_ca_topic_score_gemma":0.002101577,"domain_scores_codex":[0.9913037,0.005330271,0.0008088696,0.0007170748,0.0006590369,0.001180985],"domain_scores_gemma":[0.9928868,0.002174636,0.001934952,0.0005590413,0.0007295957,0.00171494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9815419,0.00763316,0.0002548094,0.002011306,0.0005621472,0.00005022153,0.00006902953,0.0005614407,0.0008932434,0.0003330137,0.0008727573,0.005217052],"study_design_scores_gemma":[0.9434223,0.05325465,0.0006115838,0.0001735887,0.0003146306,0.00001783834,0.00001927581,0.0002887697,0.0002583965,0.0003044422,0.0013132,0.0000212296],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.1127104,0.00133431,0.002005592,0.0008493345,0.0007598454,0.8763781,0.002455941,0.0001965551,0.003309976],"genre_scores_gemma":[0.1278201,0.0007036064,0.004593083,0.0008447522,0.0003283455,0.8633195,0.0006772046,0.00001789857,0.001695483],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.02783499,"threshold_uncertainty_score":0.0931173,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1638164984731429,"score_gpt":0.5091209678372187,"score_spread":0.3453044693640759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}