{"id":"W4409334033","doi":"10.3389/fphar.2025.1566312","title":"The venom of Cyriopagopus schmidti spider contains a natural huwentoxin-IV analogue with unexpected improved analgesic potential","year":2025,"lang":"en","type":"article","venue":"Frontiers in Pharmacology","topic":"Venomous Animal Envenomation and Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Xenon Pharmaceuticals (Canada)","funders":"Agence Nationale de la Recherche","keywords":"Venom; Spider; Analgesic; Pharmacology; Medicine; Chemistry; Biology; Zoology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006279811,0.0001682281,0.0001840878,0.0001157749,0.00005485364,0.0001571257,0.0001006386,0.0001689995,0.0004653321],"category_scores_gemma":[0.00008062616,0.00005065616,0.0001387206,0.00009486359,0.0001332438,0.0001280337,0.000111303,0.0002342394,0.00007716288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001105864,"about_ca_system_score_gemma":0.00007117805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001311876,"about_ca_topic_score_gemma":0.0002027206,"domain_scores_codex":[0.9999694,0.000005425858,0.000003119697,0.000005488957,0.000008635227,0.000008051235],"domain_scores_gemma":[0.9999771,0.000004674319,0.000005862781,0.000002494242,0.000002790921,0.000007110506],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006539171,0.000009400412,0.0001905581,0.00003679452,0.000004892121,0.0001010103,0.000008314281,0.00008965194,0.9982988,0.00005302955,0.000009222047,0.001132994],"study_design_scores_gemma":[0.00003311101,0.001205913,0.013913,0.00001211122,0.00003681393,0.001565312,0.00003213921,0.0008377201,0.9798697,0.000099568,0.002388484,0.000006132378],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971017,0.0009058592,0.001047804,0.00004042748,0.000005325789,0.00002205528,0.00009257739,0.00001285888,0.0007713237],"genre_scores_gemma":[0.9959715,0.0006944776,0.002160187,0.00005207785,0.00000597552,0.00001551747,0.0002944859,0.000004785985,0.0008009692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004653321,"threshold_uncertainty_score":0.001556695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0029175126763222,"score_gpt":0.241101025527605,"score_spread":0.2381835128512828,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}