{"id":"W4409338922","doi":"10.3390/cells14080562","title":"Glioblastoma Stem Cells at the Nexus of Tumor Heterogeneity, Immune Evasion, and Therapeutic Resistance","year":2025,"lang":"en","type":"review","venue":"Cells","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"National Cancer Institute","keywords":"Glioblastoma; Evasion (ethics); Nexus (standard); Immune system; Resistance (ecology); Stem cell; Immune surveillance; Cancer research; Biology; Immunology; Genetics; Computer science; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002180482,0.0004473656,0.001760243,0.0001400418,0.0001143021,0.00002388032,0.0002156438,0.0001603837,0.00006745946],"category_scores_gemma":[0.000006528379,0.0002497842,0.0005710855,0.0003345472,0.0001510736,0.00001272798,0.0002234471,0.0001922769,0.00007021459],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000162707,"about_ca_system_score_gemma":0.0001795136,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001014882,"about_ca_topic_score_gemma":0.0000399095,"domain_scores_codex":[0.9980835,0.0001924215,0.0006790959,0.0004764788,0.0002916265,0.0002768331],"domain_scores_gemma":[0.9978743,0.0005558128,0.0004213093,0.0009672192,0.0000831486,0.00009826263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002242027,0.0009327445,0.00005289788,0.1086183,0.002235993,0.0005425108,0.0001723897,0.000002309681,0.002486316,0.0001120573,0.008078195,0.876542],"study_design_scores_gemma":[0.0007596536,0.0002164635,0.00002755128,0.02318062,0.003412765,0.0000659725,0.00002061908,0.000001015564,0.0578241,0.00001341322,0.9142684,0.0002094817],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003606566,0.9936391,8.890801e-7,0.00007520584,0.0003476911,0.001664323,0.00009900334,0.00002179153,0.0005454057],"genre_scores_gemma":[0.002207584,0.9926693,0.00001375512,0.00009442672,0.00005249297,0.0001661311,0.00001104628,0.00004590701,0.004739322],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9061902,"threshold_uncertainty_score":0.9999954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02863229926710604,"score_gpt":0.3001653294030809,"score_spread":0.2715330301359749,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}