{"id":"W4409340592","doi":"10.1161/atvbaha.124.322244","title":"Endothelial Stiffening Induced by CD36-Mediated Lipid Uptake Leads to Endothelial Barrier Disruption and Contributes to Atherosclerotic Lesions","year":2025,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Cardiovascular Health and Disease Prevention","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Heart, Lung, and Blood Institute; National Institute on Aging","keywords":"CD36; CD31; Endothelium; Downregulation and upregulation; Biology; Endothelial stem cell; RHOA; Endothelial dysfunction; S1PR1; Cell biology; Chemistry; Internal medicine; Medicine; Endocrinology; Vascular endothelial growth factor A; Cancer research; Angiogenesis; In vitro; Receptor; Signal transduction; Biochemistry; Vascular endothelial growth factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002441804,0.0004522193,0.0003465389,0.0003722491,0.0002319585,0.0003408129,0.0001699792,0.0004889852,0.001765955],"category_scores_gemma":[0.0001542979,0.0002463843,0.0003524398,0.0002242151,0.0002962476,0.000210574,0.0003922878,0.0009295949,0.0003667107],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002761969,"about_ca_system_score_gemma":0.0001589727,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004356634,"about_ca_topic_score_gemma":0.0007294223,"domain_scores_codex":[0.9997982,0.00002908069,0.00002415689,0.0000478871,0.00005210364,0.00004858539],"domain_scores_gemma":[0.9996438,0.00002303348,0.0001596651,0.00003773153,0.00003093873,0.0001047208],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000190903,0.00003232641,0.0004794001,0.0000353139,0.000009629328,0.00006266237,0.0000131952,0.00002274642,0.9985155,0.00004514176,0.00002956677,0.0005634869],"study_design_scores_gemma":[0.00004363187,0.0006417431,0.04084162,0.00002548595,0.00008394925,0.0009734408,0.00008141414,0.001225219,0.9535469,0.0001333406,0.002390492,0.00001262039],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938388,0.00180861,0.003164197,0.0001809267,0.00003225885,0.00002125223,0.0002230106,0.00008402373,0.0006468462],"genre_scores_gemma":[0.9938373,0.001366899,0.001967361,0.000117709,0.00002067654,0.00002850619,0.0002542178,0.00001820381,0.002389053],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001765955,"threshold_uncertainty_score":0.005907774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02649003672084773,"score_gpt":0.3061805694904738,"score_spread":0.2796905327696261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}