{"id":"W4409344967","doi":"10.15283/ijsc24123","title":"Functional Validation of Alcohol Dependence-Associated <i>FYN</i> Variants Using Gene Editing and Stem Cell Study Approaches","year":2025,"lang":"en","type":"article","venue":"International Journal of Stem Cells","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"National Institute of Mental Health; National Institute on Alcohol Abuse and Alcoholism; National Institutes of Health; Kavli Foundation","keywords":"FYN; Stem cell; Gene; Computational biology; Genome editing; Alcohol; Biology; Bioinformatics; Genetics; Medicine; Computer science; Genome; Kinase; Biochemistry; Proto-oncogene tyrosine-protein kinase Src","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004862844,0.0003963947,0.0002549279,0.0003133744,0.000329619,0.0003772523,0.0003426265,0.0005327757,0.002994498],"category_scores_gemma":[0.0003968832,0.0001207532,0.0004508858,0.0001868048,0.0004350813,0.0001913567,0.0001990392,0.0007776479,0.0007562754],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004324026,"about_ca_system_score_gemma":0.0003722871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002756075,"about_ca_topic_score_gemma":0.002794034,"domain_scores_codex":[0.9997645,0.00003919706,0.00003754841,0.00006311884,0.00006285544,0.00003279553],"domain_scores_gemma":[0.9997578,0.00005207342,0.00006307587,0.00003631873,0.00005015848,0.00004051021],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001123536,0.0000397421,0.0004148242,0.00003023186,0.00001722295,0.0001278622,0.0000244961,0.0001314126,0.9968095,0.0004086698,0.0001347945,0.001748761],"study_design_scores_gemma":[0.00003133024,0.0001701398,0.004483856,0.00001146153,0.0000597314,0.001070388,0.00004374421,0.001686494,0.9850168,0.0002022839,0.007213955,0.000009732024],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9501785,0.0007806087,0.03681852,0.0005539427,0.0002533142,0.0002813328,0.006103125,0.0003125955,0.004718109],"genre_scores_gemma":[0.9768195,0.0006185085,0.01399475,0.0002852201,0.00002315871,0.0001555205,0.00377931,0.0002231092,0.00410094],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002994498,"threshold_uncertainty_score":0.01001763,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03920998411334769,"score_gpt":0.2594438612680666,"score_spread":0.2202338771547189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}