{"id":"W4409349602","doi":"10.21203/rs.3.rs-6217777/v1","title":"Metavac®-RSV mucosal bivalent vaccine candidate protects cotton rats against RSV and HMPV and its production process in serum-free Vero cells is scalable in a 2L bioreactor","year":2025,"lang":"en","type":"preprint","venue":"Research Square","topic":"Animal Virus Infections Studies","field":"Agricultural and Biological Sciences","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; Medical Research Council; Région Auvergne-Rhône-Alpes; Centre National de la Recherche Scientifique; Association Nationale de la Recherche et de la Technologie; Université Laval","keywords":"Vero cell; Bivalent (engine); Virology; Biology; Microbiology; Chemistry; Virus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002357662,0.0002901492,0.0002666296,0.0001926143,0.0001257144,0.0003105776,0.0002241196,0.0002544219,0.001333981],"category_scores_gemma":[0.0001327924,0.0001363128,0.0003437973,0.0001380953,0.0001247947,0.0002118882,0.0002211967,0.0004588176,0.0007669963],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000228319,"about_ca_system_score_gemma":0.0002188463,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004767376,"about_ca_topic_score_gemma":0.0005767918,"domain_scores_codex":[0.9997966,0.00002547042,0.00001297965,0.00005026553,0.00007744062,0.00003726344],"domain_scores_gemma":[0.9999499,0.000006931204,0.00001497767,0.000009358584,0.000009219873,0.000009632921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002625389,0.000009849813,0.00003885788,0.000009638852,9.471573e-7,0.000007109746,0.000004401106,0.00002740953,0.9993555,0.000020229,0.00001461217,0.000485254],"study_design_scores_gemma":[0.00000513638,0.000181889,0.0006387316,0.000002829189,0.000007910525,0.00004616415,0.00000931501,0.0005331349,0.9971526,0.00001790353,0.001402159,0.000002274493],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9713637,0.0009549132,0.02387189,0.0001477404,0.0001095496,0.0001290365,0.0009306383,0.0003246793,0.002167959],"genre_scores_gemma":[0.969891,0.0005608511,0.02010577,0.00005881613,0.00003460687,0.0001182592,0.00163747,0.0000759808,0.007517309],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001333981,"threshold_uncertainty_score":0.0044626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05290678466186512,"score_gpt":0.3385868428919949,"score_spread":0.2856800582301298,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}