{"id":"W4409351113","doi":"10.1038/s41576-025-00836-z","title":"The regulation and function of post-transcriptional RNA splicing","year":2025,"lang":"en","type":"review","venue":"Nature Reviews Genetics","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Biology; RNA splicing; Function (biology); Computational biology; Rna processing; RNA; Post-transcriptional regulation; Alternative splicing; Genetics; Cell biology; Gene; Exon","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006537296,0.0002626806,0.0006644923,0.000078269,0.0001473964,0.00003319959,0.0002508507,0.0006487549,0.000004723302],"category_scores_gemma":[0.0002917542,0.000165375,0.0003635276,0.0002076149,0.00008164279,0.000002124832,0.0001036503,0.0004862709,0.000002675463],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001864723,"about_ca_system_score_gemma":0.0002392009,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001924532,"about_ca_topic_score_gemma":0.00002084158,"domain_scores_codex":[0.9983934,0.000269129,0.0005755009,0.0003500125,0.0002033185,0.000208595],"domain_scores_gemma":[0.9988862,0.00007640442,0.0002976225,0.000487962,0.0001925731,0.00005918969],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001224622,0.000006975792,0.000002240338,0.008614444,0.00007204094,1.857211e-7,0.000001525898,7.060111e-7,0.007459631,0.0002980257,0.001005429,0.9825265],"study_design_scores_gemma":[0.00007774297,0.00009530912,0.00008044026,0.004230673,0.0002937887,0.000007610389,0.000002466126,0.00000507659,0.0001647643,0.0000318731,0.9948717,0.0001385588],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001079905,0.9980576,0.0003018759,0.00003591521,0.000227406,0.0009308954,0.00003109311,0.000003479026,0.0003037483],"genre_scores_gemma":[0.00003601745,0.9965138,0.00031627,0.00007341088,0.000275617,0.00005334985,0.0003058422,0.00002123945,0.002404444],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9938663,"threshold_uncertainty_score":0.6743796,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01884524269145927,"score_gpt":0.3300655813868493,"score_spread":0.31122033869539,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}