{"id":"W4409356518","doi":"10.1126/sciadv.adp8504","title":"Astrocytic RNA editing regulates the host immune response to alpha-synuclein","year":2025,"lang":"en","type":"article","venue":"Science Advances","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"Francis Crick Institute; Wellcome Trust; Medical Research Council; Eisai; Michael J. Fox Foundation for Parkinson's Research","keywords":"RNA editing; Neuroinflammation; RNA; Biology; Astrocyte; Cell biology; ADAR; RNA-binding protein; Microglia; Alpha-synuclein; Innate immune system; Immune system; Parkinson's disease; Inflammation; Neuroscience; Immunology; Biochemistry; Central nervous system; Medicine; Gene; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001128404,0.0001681883,0.00008882942,0.00009604662,0.0001195861,0.0002756231,0.00005773285,0.0001488446,0.0005387736],"category_scores_gemma":[0.00006655855,0.00006119747,0.000127338,0.0000561727,0.0001525753,0.0001215187,0.0001029432,0.0002322606,0.0001988247],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001385069,"about_ca_system_score_gemma":0.00008352048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001586019,"about_ca_topic_score_gemma":0.0003837159,"domain_scores_codex":[0.9999233,0.0000188478,0.000005143736,0.00001615434,0.00001874955,0.00001782024],"domain_scores_gemma":[0.9999537,0.000007176721,0.00001432072,0.000003789997,0.000009268468,0.00001164886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005543506,0.000009062418,0.0003275633,0.00001449215,0.000002207494,0.0000866757,0.00001767089,0.00004741693,0.9978645,0.0001366416,0.00002456498,0.001413692],"study_design_scores_gemma":[0.00001745237,0.0004324414,0.02581393,0.00001184936,0.00002626916,0.0006585416,0.0001159948,0.002144384,0.9660095,0.0003796534,0.004383798,0.000006105156],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894381,0.003832953,0.003492642,0.0001519564,0.0000364893,0.00001840944,0.0001060174,0.00006089417,0.002862602],"genre_scores_gemma":[0.9968182,0.001042003,0.00100213,0.00003497719,0.00001034482,0.000006154987,0.00005456598,0.00000535894,0.001026184],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005387736,"threshold_uncertainty_score":0,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00543923665878243,"score_gpt":0.2758796974504166,"score_spread":0.2704404607916341,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}