{"id":"W4409358012","doi":"10.1093/cid/ciaf191","title":"Viral Suppression, Viral Failure, and Safety Outcomes in Children and Adolescents With HIV on Dolutegravir in Europe and Thailand","year":2025,"lang":"en","type":"article","venue":"Clinical Infectious Diseases","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Imperial College Healthcare NHS Trust; University College London; Imperial College London; ViiV Healthcare; St George's University Hospitals NHS Foundation Trust; Clinical Trials Fund, Canadian Institutes of Health Research; University Hospital Southampton NHS Foundation Trust; McMaster University; Medical Research Council Canada; Alder Hey Children's NHS Foundation Trust; Gilead Sciences","keywords":"Medicine; Discontinuation; Dolutegravir; Viral load; Cumulative incidence; Adverse effect; Internal medicine; Incidence (geometry); Human immunodeficiency virus (HIV); Cohort; Antiretroviral therapy; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001012832,0.0002242927,0.0002520288,0.0006206074,0.0004264751,0.0008719861,0.0002257967,0.0002772826,0.0007813434],"category_scores_gemma":[0.002099805,0.0001555702,0.000436656,0.001144273,0.0004610819,0.0004586962,0.0006366525,0.0005417877,0.00007834453],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006792616,"about_ca_system_score_gemma":0.00121832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01471968,"about_ca_topic_score_gemma":0.01364437,"domain_scores_codex":[0.999357,0.0002339682,0.00008619489,0.00007761859,0.0001100198,0.0001350748],"domain_scores_gemma":[0.9975725,0.0003221653,0.001191826,0.00004746444,0.0002340771,0.0006319919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001816103,0.00003164633,0.9975762,0.00002151344,0.00003594652,0.0001817742,0.0002028647,0.0000601623,0.00003691696,0.00001681247,0.00006972004,0.001584821],"study_design_scores_gemma":[0.00003393733,0.0004666299,0.9959453,0.00006312622,0.00004861284,0.001043631,0.001812655,0.0002049294,0.00006670345,0.00002702506,0.0002810681,0.000006379232],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999218,0.0002914571,0.00001651461,0.00002515786,0.000001662068,0.000006952542,0.0002241954,6.274228e-7,0.0002153561],"genre_scores_gemma":[0.9993252,0.0002323837,0.00003166544,0.00002326171,0.000004267811,0.0000118319,0.0003230173,7.942073e-7,0.00004762116],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01471968,"threshold_uncertainty_score":0.02926797,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007076144534294257,"score_gpt":0.2921953868292679,"score_spread":0.2851192422949736,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}