{"id":"W4409358150","doi":"10.1038/s43856-025-00830-w","title":"Modifying the glycosylation profile of SARS-CoV-2 spike-based subunit vaccines alters focusing of the humoral immune response in a mouse model","year":2025,"lang":"en","type":"article","venue":"Communications Medicine","topic":"Transgenic Plants and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Natural Sciences and Engineering Research Council of Canada; University of Ottawa; Université de Montréal; National Research Council Canada","funders":"National Institutes of Health; Fundação para a Ciência e a Tecnologia; Ministério da Ciência, Tecnologia e Ensino Superior; National Institute of Allergy and Infectious Diseases; European Commission","keywords":"Glycosylation; Immune system; Antigen; Glycan; Protein subunit; Biology; Chinese hamster ovary cell; Antibody; Virology; Glycoprotein; Immunology; Receptor; Molecular biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002321426,0.0006275433,0.0002450193,0.0004363762,0.0001030207,0.00031286,0.0002457938,0.0005110796,0.001395317],"category_scores_gemma":[0.0001259929,0.0001764574,0.0003930973,0.0001479242,0.0002385988,0.0003257112,0.0001331228,0.001247516,0.0003841298],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000272815,"about_ca_system_score_gemma":0.0001367367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002811752,"about_ca_topic_score_gemma":0.0002958211,"domain_scores_codex":[0.9998029,0.00003077435,0.00001859516,0.0000450977,0.00004279405,0.00005988782],"domain_scores_gemma":[0.9998102,0.00002469314,0.00006647656,0.00002497354,0.00002068508,0.00005292337],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003395068,0.0001476745,0.0001568865,0.00002012607,0.000005734781,0.00002354718,0.00001006594,0.00004896186,0.9986811,0.00004593663,0.00002863051,0.0004917004],"study_design_scores_gemma":[0.00004709697,0.002597722,0.002841316,0.00001061053,0.00003116775,0.0001737185,0.0000252964,0.0006762508,0.9924932,0.00005053991,0.001047855,0.000005315622],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965906,0.0004252526,0.001363671,0.0001013804,0.00004771107,0.00004208295,0.0004383823,0.00007271061,0.0009182795],"genre_scores_gemma":[0.9926689,0.0006581529,0.002019429,0.0001164252,0.00002237012,0.00006603574,0.0008166649,0.00003795873,0.00359414],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001395317,"threshold_uncertainty_score":0.004667819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05834614925671838,"score_gpt":0.3397059194659646,"score_spread":0.2813597702092462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}