{"id":"W4409359917","doi":"10.1016/j.neurobiolaging.2025.04.002","title":"Dynamics and role of covalently-closed circular RNAs in Alzheimer's disease: A review of experimental and bioinformatics studies","year":2025,"lang":"en","type":"review","venue":"Neurobiology of Aging","topic":"Circular RNAs in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Disease; Bioinformatics; Neuroscience; Alzheimer's disease; Computational biology; Medicine; Biology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001408723,0.001069778,0.001597031,0.003869924,0.0003740924,0.001537515,0.0008463463,0.001120205,0.001282781],"category_scores_gemma":[0.002108524,0.0005607698,0.001309392,0.003358444,0.0007146819,0.002278774,0.0006582431,0.001061479,0.0006203029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007024147,"about_ca_system_score_gemma":0.001205436,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00154543,"about_ca_topic_score_gemma":0.001051434,"domain_scores_codex":[0.9994909,0.0000786961,0.00007752318,0.0001622901,0.000154915,0.00003565915],"domain_scores_gemma":[0.9982013,0.00107206,0.000234602,0.00006907766,0.0003583878,0.00006453924],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002723207,0.0001506446,0.004873222,0.0341295,0.0004998314,0.0005185606,0.0003067931,0.003997854,0.01661884,0.006934877,0.01349313,0.9182044],"study_design_scores_gemma":[0.00006817338,0.0009091773,0.01955832,0.01217489,0.002983283,0.005775353,0.0007063479,0.01585004,0.02512065,0.02189872,0.8944847,0.0004703102],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001943527,0.9925767,0.003901012,0.0004029842,0.0001860891,0.00001408925,0.0001459114,0.00006000471,0.0007696429],"genre_scores_gemma":[0.009478498,0.9860475,0.003241734,0.0002332282,0.0003660493,0.00002364183,0.000249669,0.00001353271,0.0003462279],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003869924,"threshold_uncertainty_score":0.007450163,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02024294845414539,"score_gpt":0.3307220981402107,"score_spread":0.3104791496860653,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}