{"id":"W4409360507","doi":"10.1158/1055-9965.epi-24-1440","title":"Causal Effects of Breast Cancer Risk Factors across Hormone Receptor Breast Cancer Subtypes: A Two-Sample Mendelian Randomization Study","year":2025,"lang":"en","type":"article","venue":"Cancer Epidemiology Biomarkers & Prevention","topic":"Cancer Risks and Factors","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; National Cancer Institute; Seventh Framework Programme; KWF Kankerbestrijding; Ministerie van Volksgezondheid, Welzijn en Sport; Canadian Institutes of Health Research; Gray Foundation; Horizon 2020 Framework Programme; University of Cambridge; Cancer Research UK; Government of Canada; Ministère de l'Économie, de la Science et de l'Innovation - Québec; Wellcome Trust; Susan G. Komen; Genome Canada; Fondation du cancer du sein du Québec; National Institutes of Health; Ovarian Cancer Research Fund; European Commission; Breast Cancer Research Foundation; U.S. Department of Defense","keywords":"Mendelian randomization; Breast cancer; Oncology; Medicine; Internal medicine; Body mass index; Risk factor; Menarche; Cancer; Biology; Genotype; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1198395,0.002430454,0.004145391,0.002058316,0.001386901,0.00180535,0.003162248,0.00305559,0.003934419],"category_scores_gemma":[0.2187293,0.00112336,0.006784516,0.001903525,0.002776904,0.001362479,0.001503087,0.001630691,0.0002941018],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00126496,"about_ca_system_score_gemma":0.001862522,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003442346,"about_ca_topic_score_gemma":0.001873551,"domain_scores_codex":[0.838695,0.1360807,0.005401394,0.01360426,0.004676664,0.001541952],"domain_scores_gemma":[0.7657116,0.1771303,0.01729366,0.03496831,0.003747608,0.001148546],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1170729,0.004078863,0.4889833,0.004307168,0.1348851,0.008713158,0.003534366,0.02892569,0.01288655,0.06502376,0.008060232,0.123529],"study_design_scores_gemma":[0.08089069,0.02478375,0.1942808,0.001024972,0.1362634,0.01360768,0.0008171654,0.3751668,0.009091912,0.1474421,0.01562398,0.001006666],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6073031,0.004160575,0.3774466,0.001368231,0.0007453925,0.005164347,0.001430986,0.0009035784,0.001477244],"genre_scores_gemma":[0.9093757,0.0003671787,0.08502033,0.0008062428,0.0001599774,0.003007549,0.0006347054,0.00008599045,0.0005421987],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1198395,"threshold_uncertainty_score":0.6337794,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02286411971178402,"score_gpt":0.3793449825425681,"score_spread":0.3564808628307841,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}