{"id":"W4409361735","doi":"10.3390/cells14080578","title":"The Role of GREMLIN1, a Bone Morphogenetic Protein Antagonist, in Cancer Stem Cell Regulation","year":2025,"lang":"en","type":"review","venue":"Cells","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Queen's University; Queen's University Belfast; National Centre for the Replacement, Refinement and Reduction of Animals in Research","keywords":"Cancer stem cell; Bone morphogenetic protein; Cancer research; Biology; Noggin; Metastasis; Cancer; Carcinogenesis; Tumor microenvironment; Stem cell; Cell biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001859646,0.0002575197,0.0005144558,0.00006566467,0.00006372375,0.00002074364,0.0003408425,0.0002767861,0.00001309918],"category_scores_gemma":[0.00001322622,0.0001979768,0.0002409787,0.0001697951,0.00009585076,0.000001037972,0.0001332247,0.0001352821,0.000007044853],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004234734,"about_ca_system_score_gemma":0.0007308332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003181507,"about_ca_topic_score_gemma":0.00004313171,"domain_scores_codex":[0.9985269,0.0002157064,0.0005288058,0.0003828205,0.0001269057,0.0002188946],"domain_scores_gemma":[0.9989209,0.00004024401,0.0003614315,0.0005737512,0.00006022465,0.00004341413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003360322,0.0001110932,0.00001038065,0.01059754,0.00007153826,0.00000324983,0.00001690182,0.000108898,0.1553833,0.00001091602,0.0004354235,0.8332171],"study_design_scores_gemma":[0.0001077284,0.00002822753,0.000003434906,0.003112831,0.0001201323,6.862926e-7,0.00001030784,0.000007685449,0.2692905,0.00001733875,0.7271341,0.0001670491],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001531055,0.9968799,0.00001561818,0.00000350599,0.00009693152,0.0009835955,0.0001084253,0.00000599991,0.0003749421],"genre_scores_gemma":[0.004307845,0.9896875,0.00005683455,0.000006335599,0.000117613,0.000347315,0.0001408397,0.00003624692,0.005299477],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8330501,"threshold_uncertainty_score":0.807326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01092966429464973,"score_gpt":0.2716712154951397,"score_spread":0.26074155120049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}