{"id":"W4409361735","doi":"10.3390/cells14080578","title":"The Role of GREMLIN1, a Bone Morphogenetic Protein Antagonist, in Cancer Stem Cell Regulation","year":2025,"lang":"en","type":"review","venue":"Cells","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Queen's University; Queen's University Belfast; National Centre for the Replacement, Refinement and Reduction of Animals in Research","keywords":"Cancer stem cell; Bone morphogenetic protein; Cancer research; Biology; Noggin; Metastasis; Cancer; Carcinogenesis; Tumor microenvironment; Stem cell; Cell biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002543528,0.0003504737,0.0002581403,0.0004062823,0.0001962199,0.000630387,0.0003257987,0.0004959591,0.0007100313],"category_scores_gemma":[0.0002441772,0.0001105475,0.0002243475,0.0002414707,0.0005492815,0.0003292104,0.0004469042,0.0007558765,0.0004108812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006606791,"about_ca_system_score_gemma":0.0004313271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006511202,"about_ca_topic_score_gemma":0.0006132137,"domain_scores_codex":[0.9998296,0.00003855281,0.000009307545,0.00003740881,0.0000530525,0.00003199315],"domain_scores_gemma":[0.99988,0.0000187413,0.0000449023,0.000005321802,0.00002145097,0.00002956093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004042095,0.000081602,0.003121157,0.001485568,0.00005310449,0.0007401527,0.0001967258,0.001500836,0.8201927,0.01581695,0.005664188,0.1507428],"study_design_scores_gemma":[0.0001329043,0.0010749,0.02698479,0.0003879475,0.0001480516,0.004012777,0.0004837874,0.005406381,0.4981642,0.01076107,0.452362,0.00008125999],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2297628,0.7232149,0.01747286,0.007950888,0.0007092871,0.0001006371,0.0008045664,0.0006187562,0.01936541],"genre_scores_gemma":[0.79735,0.1851051,0.006399155,0.001766447,0.0003416261,0.00008119999,0.0007301554,0.00007153978,0.00815478],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0007100313,"threshold_uncertainty_score":0.004793525,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01092966429464973,"score_gpt":0.2716712154951397,"score_spread":0.26074155120049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}