{"id":"W4409365518","doi":"10.1093/jbmrpl/ziaf061","title":"Real-world differences in denosumab persistence, reinitiation, and switching among cohorts of older adults in Canada and the United States","year":2025,"lang":"en","type":"article","venue":"JBMR Plus","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Public Health; Public Health Ontario; University of Toronto","funders":"Office of Disease Prevention; NIH Office of the Director; Genentech; GlaxoSmithKline; University of Toronto; National Institutes of Health; National Institute on Aging; Brown University; Sanofi","keywords":"Persistence (discontinuity); Denosumab; Demography; Gerontology; Medicine; Psychology; Internal medicine; Osteoporosis; Sociology; Engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005379268,0.0004194124,0.0006616325,0.00121496,0.001537836,0.00155223,0.001385792,0.0007757479,0.0008658461],"category_scores_gemma":[0.01329334,0.000429888,0.00112037,0.002894244,0.001080243,0.0006102281,0.00128045,0.001084728,0.0001410304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.008223468,"about_ca_system_score_gemma":0.008100179,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.9346093,"about_ca_topic_score_gemma":0.9342991,"domain_scores_codex":[0.9966433,0.0008374152,0.0003440805,0.0008481325,0.0005521579,0.0007750381],"domain_scores_gemma":[0.9927677,0.001318104,0.002307038,0.00100544,0.001630986,0.0009707162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001812855,0.00002474255,0.996816,0.00001083899,0.0002036736,0.00002508509,0.0002921086,0.0004802222,0.00004258336,0.0001475195,0.000415331,0.001360746],"study_design_scores_gemma":[0.00002648121,0.00002839334,0.9965533,0.00001960021,0.00009322806,0.00003602248,0.0003508486,0.002032361,0.00004321118,0.00009413918,0.000702943,0.00001957668],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936143,0.0003427277,0.0003747697,0.0002299717,0.00001128234,0.0000551009,0.004845639,0.00001372897,0.0005125916],"genre_scores_gemma":[0.9949823,0.0001447702,0.000430856,0.0001395936,0.000009984454,0.00004848693,0.00397701,0.0000078511,0.0002592955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06539071,"threshold_uncertainty_score":0.1315516,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01561423716136068,"score_gpt":0.2812437461594792,"score_spread":0.2656295089981185,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}