{"id":"W4409370723","doi":"10.1038/s41594-025-01529-1","title":"Structural insights into RNA-guided RNA editing by the Cas13b–ADAR2 complex","year":2025,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"RNA; RNA editing; Computational biology; Riboswitch; RNA-binding protein; Nucleic acid structure; Biology; Non-coding RNA; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003370492,0.0004712993,0.0004359556,0.0001929039,0.0005207473,0.001039747,0.0006982766,0.0007928129,0.002820748],"category_scores_gemma":[0.0002609063,0.0003760794,0.000329024,0.0001163591,0.0003405358,0.0006475145,0.0003114895,0.001593435,0.001035192],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008995386,"about_ca_system_score_gemma":0.0004357934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001169467,"about_ca_topic_score_gemma":0.001396184,"domain_scores_codex":[0.9998436,0.00001864151,0.00001223926,0.00004068699,0.00005843052,0.00002641352],"domain_scores_gemma":[0.9998795,0.00003010353,0.00002344027,0.00001322647,0.00001328834,0.00004046602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003325524,0.00007745355,0.0004866533,0.000170316,0.00003276061,0.0007135557,0.00009669884,0.003364437,0.9796896,0.007759788,0.0008548724,0.00642123],"study_design_scores_gemma":[0.0001234781,0.0002106417,0.002885138,0.00003069571,0.00004344869,0.001559058,0.0001930179,0.05500761,0.9129766,0.003860563,0.02303483,0.00007487284],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9369881,0.008101442,0.03746723,0.002777137,0.0004101594,0.00005542545,0.0005672915,0.0009503181,0.01268292],"genre_scores_gemma":[0.9863446,0.001022191,0.0095022,0.0002717669,0.0000308658,0.00001051231,0.0002590422,0.00006890509,0.002489901],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002820748,"threshold_uncertainty_score":0.009436369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005933105583460345,"score_gpt":0.3035668967420506,"score_spread":0.2976337911585903,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}