{"id":"W4409373741","doi":"10.1093/hmg/ddaf047","title":"Deoxynucleoside supplementation ameliorates the disease associated phenotypes in a zebrafish model of <i>RRM2B</i> mtDNA depletion syndrome","year":2025,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Genome British Columbia; Wellcome Trust; University of Victoria","keywords":"Zebrafish; Biology; Mitochondrial DNA; Genetics; Mitochondrial disease; Nuclear DNA; Mutation; Mitochondrion; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002420585,0.0008000371,0.0007109634,0.0005241295,0.0003274117,0.0003034501,0.0005036427,0.0008737972,0.002201697],"category_scores_gemma":[0.000206723,0.0002741393,0.0006233494,0.0001437348,0.0004387872,0.0003993756,0.000364076,0.001483737,0.0003755979],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005245659,"about_ca_system_score_gemma":0.0005722746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0038997,"about_ca_topic_score_gemma":0.007452608,"domain_scores_codex":[0.9997826,0.00002360507,0.00002959187,0.00005707867,0.00006825483,0.00003883876],"domain_scores_gemma":[0.9998007,0.00001681423,0.00006687539,0.00001262229,0.00002889918,0.00007413529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002760037,0.00005354808,0.0001782891,0.0001188602,0.00001593757,0.0001663573,0.00003051875,0.00008867739,0.9974586,0.00008938192,0.0001825961,0.001341216],"study_design_scores_gemma":[0.0002198615,0.003575893,0.009781313,0.0001103811,0.0002143042,0.0009026398,0.0001891769,0.002158028,0.9732441,0.0002850458,0.009266353,0.00005290315],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820946,0.004435229,0.005906412,0.0009867072,0.0002521408,0.0001580584,0.002656772,0.0005968802,0.002913116],"genre_scores_gemma":[0.9756339,0.00415871,0.006918906,0.0004683116,0.00003307596,0.0003535256,0.002383804,0.0001432988,0.009906519],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0038997,"threshold_uncertainty_score":0.007753968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01202662128620747,"score_gpt":0.2612139041755197,"score_spread":0.2491872828893122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}