{"id":"W4409378063","doi":"10.1002/trc2.70081","title":"Measuring time saved in Alzheimer's disease: What is a meaningful slowing of progression?","year":2025,"lang":"en","type":"article","venue":"Alzheimer s & Dementia Translational Research & Clinical Interventions","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Novo Nordisk; Northern California Institute for Research and Education; Pfizer; Novartis Pharmaceuticals Corporation; Biogen; Eli Lilly and Company; BioClinica; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Eisai; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Disease; Alzheimer's disease; Medicine; Neuroscience; Gerontology; Internal medicine; Psychology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02025744,0.0009938215,0.0008300276,0.0008808068,0.0002930838,0.002578138,0.00138526,0.001210074,0.003175087],"category_scores_gemma":[0.06212664,0.0002996452,0.001576867,0.0009627715,0.001406681,0.002122685,0.001203139,0.001363564,0.0003212543],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002555104,"about_ca_system_score_gemma":0.001905293,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003542943,"about_ca_topic_score_gemma":0.0021691,"domain_scores_codex":[0.9873245,0.01019523,0.0004090695,0.0007720147,0.0009878672,0.0003113467],"domain_scores_gemma":[0.9623268,0.02907063,0.00463766,0.001481579,0.001604097,0.0008792696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.004077482,0.0004485387,0.1115855,0.002677821,0.002018719,0.0004084676,0.001302168,0.7226043,0.001895928,0.05519528,0.006611817,0.09117408],"study_design_scores_gemma":[0.001282551,0.01052044,0.1360305,0.004780995,0.002775641,0.00120769,0.002653032,0.4710735,0.007388598,0.3252692,0.03646403,0.000553895],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.8017422,0.01403399,0.1336594,0.01145033,0.0004582291,0.001312271,0.01041755,0.0003352757,0.02659086],"genre_scores_gemma":[0.9853333,0.001236841,0.01154294,0.0003193974,0.00002612263,0.0004509878,0.0007205892,0.00001928501,0.000350562],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.02025744,"threshold_uncertainty_score":0.1071328,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2712198670394936,"score_gpt":0.5232158127988139,"score_spread":0.2519959457593203,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}