{"id":"W4409378474","doi":"10.1007/s11357-025-01642-5","title":"Cerebral hypoperfusion, brain structural integrity, and cognitive impairment in older APOE4 carriers","year":2025,"lang":"en","type":"article","venue":"GeroScience","topic":"Cerebrovascular and genetic disorders","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Canadian Institute for Military and Veteran Health Research; University of Southern California; Foundation for the National Institutes of Health","keywords":"Cognitive impairment; Cerebral hypoperfusion; Cognition; Structural integrity; Neuroscience; Medicine; Perfusion; Psychology; Cardiology; Internal medicine; Engineering","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004985589,0.0003491296,0.0002731294,0.0006076735,0.0002506717,0.0003172196,0.0001781235,0.0003764227,0.0008513149],"category_scores_gemma":[0.001506842,0.0002031602,0.0002423828,0.000318396,0.0003377074,0.000281761,0.0002564772,0.0002483051,0.0001178205],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000185165,"about_ca_system_score_gemma":0.0001345386,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004861155,"about_ca_topic_score_gemma":0.005023778,"domain_scores_codex":[0.9998959,0.00002955901,0.00001030284,0.00002211601,0.00001758367,0.00002450401],"domain_scores_gemma":[0.9994981,0.0001160273,0.0002334792,0.00003192303,0.00003335896,0.00008704043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001374396,0.0001286701,0.9930224,0.00001483599,0.0001022551,0.0005642559,0.0002923491,0.00004978712,0.00196416,0.0000243113,0.00003985287,0.002422685],"study_design_scores_gemma":[0.00001045391,0.0001962928,0.9991361,0.000001843768,0.00002927638,0.0003173552,0.0000726986,0.00005876777,0.0001114321,0.00003435893,0.00002956151,0.000001921883],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999792,0.00009925366,0.00001353487,0.000006911787,7.341965e-7,0.000001281994,0.00001575398,6.969063e-7,0.0000698899],"genre_scores_gemma":[0.9997404,0.00006195351,0.00003308137,0.00001027291,0.000003725671,0.000001887457,0.00005219726,4.971704e-7,0.00009596453],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004861155,"threshold_uncertainty_score":0.009665728,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008148319298853832,"score_gpt":0.2857554337707844,"score_spread":0.2776071144719305,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}