{"id":"W4409380819","doi":"10.1038/s41419-025-07579-z","title":"Loss of the APP regulator RHBDL4 preserves memory in an Alzheimer’s disease mouse model","year":2025,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McMaster University; McGill University","funders":"National Institute on Aging; Lady Davis Institute for Medical Research; Fonds de Recherche du Québec - Santé; Canada First Research Excellence Fund; University of Oxford; Canadian Institutes of Health Research; Alzheimer Society; Scottish Rite Charitable Foundation of Canada; McGill University; Natural Sciences and Engineering Research Council of Canada; Pfizer","keywords":"Regulator; Disease; Alzheimer's disease; Cell biology; Biology; Neuroscience; Medicine; Genetics; Gene; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009093079,0.00021933,0.0002700634,0.0001371746,0.0001123354,0.00002777845,0.0001958264,0.0000523266,0.00004282739],"category_scores_gemma":[0.0001006915,0.0001513596,0.0001638136,0.0001991204,0.0002140854,0.0001700405,0.0001723902,0.000125394,0.000005288894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003473982,"about_ca_system_score_gemma":0.001116504,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005681238,"about_ca_topic_score_gemma":0.000008742062,"domain_scores_codex":[0.9985013,0.00009718144,0.0002529365,0.0004245527,0.0003579817,0.000366046],"domain_scores_gemma":[0.9972981,0.00004045024,0.00005380138,0.0008495062,0.00009087362,0.001667336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004886273,0.003406405,0.9860049,0.0007138576,0.0007541361,0.0002575415,0.00009751159,0.0004692564,0.0001499188,0.001080659,0.001086897,0.00109265],"study_design_scores_gemma":[0.005313017,0.00008654025,0.9508284,0.0002236307,0.002245598,6.458819e-7,0.00008516743,0.03311571,0.001961867,0.005865323,0.00004157588,0.0002325255],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9681681,0.02873491,0.00001075039,0.000539311,0.00002977275,0.0009632449,0.0002646806,0.00003820007,0.00125098],"genre_scores_gemma":[0.9978891,0.0002564766,0.00005885951,0.000333123,0.00002714716,0.0001093205,0.00008554884,0.00002198433,0.001218458],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03517649,"threshold_uncertainty_score":0.6172267,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03026899648867165,"score_gpt":0.3052562968643175,"score_spread":0.2749873003756458,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}