{"id":"W4409391705","doi":"10.1002/alz.70130","title":"The effect of Alzheimer's disease genetic factors on limbic white matter microstructure","year":2025,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; National Institute of Neurological Disorders and Stroke; Takeda Pharmaceutical Company; IXICO; H. Lundbeck A/S; Servier; Vanderbilt University Medical Center; Northern California Institute for Research and Education; Pfizer; BioClinica; Biogen; Illinois Department of Public Health; GE Healthcare; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Vanderbilt University; Alzheimer's Drug Discovery Foundation; Meso Scale Diagnostics; Fujirebio Europe; Alzheimer's Association","keywords":"White matter; Disease; White (mutation); Neuroscience; Medicine; Psychology; Internal medicine; Genetics; Biology; Magnetic resonance imaging; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006538785,0.0005857727,0.00028902,0.0006255461,0.0002947783,0.0005851101,0.0002583557,0.0003303341,0.001864886],"category_scores_gemma":[0.001801878,0.0001463593,0.0005899697,0.0007214483,0.0003272166,0.0002300373,0.0003343101,0.0002768533,0.000191264],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002524694,"about_ca_system_score_gemma":0.0002949442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005373195,"about_ca_topic_score_gemma":0.005403668,"domain_scores_codex":[0.9996934,0.00008021354,0.00003419974,0.0001073593,0.00005180971,0.00003304955],"domain_scores_gemma":[0.998892,0.0002874512,0.0004720976,0.0001492976,0.0001014062,0.00009768428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001041701,0.00003602144,0.9849073,0.0000326919,0.0007336872,0.0002057878,0.0000891087,0.0002873673,0.005186291,0.0001231032,0.0001403042,0.007216556],"study_design_scores_gemma":[0.000004681721,0.00007942839,0.9984717,0.000006077335,0.0001419603,0.0002018838,0.00002068195,0.0002994048,0.0004965381,0.0001397235,0.0001349917,0.000002876501],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980622,0.0005853173,0.0003876282,0.00004105972,0.000004756499,0.000004630461,0.0004722168,0.00001180489,0.0004303826],"genre_scores_gemma":[0.9989761,0.000124049,0.0003434378,0.00001354375,0.0000048267,0.000004327521,0.0002152828,0.000005488539,0.0003128212],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005373195,"threshold_uncertainty_score":0.01068383,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009059024591234676,"score_gpt":0.2864057866243416,"score_spread":0.2773467620331069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}