{"id":"W4409403742","doi":"10.1101/2025.04.13.648598","title":"Proteolytically activated antibacterial toxins inhibit the growth of diverse Gram-positive bacteria","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Microbial Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Gram; Bacteria; Microbiology; Gram-negative bacteria; Gram-positive bacteria; Biology; Chemistry; Biochemistry; Escherichia coli; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001223841,0.0004227637,0.0001771796,0.0002291521,0.0001037626,0.0001809632,0.0001428636,0.000227959,0.0008360178],"category_scores_gemma":[0.0001309208,0.00007820487,0.0002346111,0.0001603393,0.0001433675,0.0001485202,0.0001965052,0.0003159495,0.0003721916],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001066948,"about_ca_system_score_gemma":0.0001330246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000212167,"about_ca_topic_score_gemma":0.0002883801,"domain_scores_codex":[0.9998507,0.00002619808,0.0000153099,0.00001750207,0.00006028326,0.0000299773],"domain_scores_gemma":[0.9998828,0.00001968165,0.00003225157,0.00001401557,0.00002602535,0.00002515147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003711365,0.00003063122,0.0001792042,0.00002466227,0.000002775534,0.00002520333,0.000002418485,0.0000220935,0.9985982,0.00002191653,0.00002743163,0.001028378],"study_design_scores_gemma":[0.00001184004,0.0005320172,0.005831351,0.000006358831,0.000009890146,0.0002809328,0.00001523742,0.0004157176,0.9914044,0.00003119562,0.001459408,0.000001706734],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878641,0.004987011,0.004051416,0.0001610225,0.00006794147,0.00005809551,0.0003532584,0.00009525814,0.002361898],"genre_scores_gemma":[0.9915344,0.001623561,0.003716672,0.0001137882,0.00002735849,0.00003150409,0.0005975612,0.00001390155,0.002341313],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008360178,"threshold_uncertainty_score":0.002796769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007674407125592349,"score_gpt":0.2160204483272857,"score_spread":0.2083460412016934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}