{"id":"W4409408715","doi":"10.1186/s40364-025-00769-z","title":"IL1RAP is an immunotherapeutic target for normal karyotype triple-mutated acute myeloid leukemia","year":2025,"lang":"en","type":"article","venue":"Biomarker Research","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec; Princess Margaret Cancer Centre; University of Toronto; Université de Montréal; Medical Council of Canada; Hôpital Maisonneuve-Rosemont; National Research Council Canada; Centre Hospitalier Universitaire Sainte-Justine; Institute for Research in Immunology and Cancer","funders":"Cole Foundation; Fonds de Recherche du Québec - Santé; Alliance de recherche numérique du Canada; CHU Sainte-Justine Foundation; Institut de Valorisation des Données; Canada First Research Excellence Fund; Fondation Charles-Bruneau; Université de Montréal; Stem Cell Network; Government of Canada; Génome Québec; Canadian Institutes of Health Research; Genome Canada","keywords":"NPM1; Myeloid leukemia; Medicine; Cancer research; Haematopoiesis; Myeloid; Leukemia; Antigen; Stem cell; Immunology; Karyotype; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001317111,0.0003766059,0.0004135447,0.0005504009,0.0001923925,0.0005255292,0.0001825705,0.0002887867,0.001224279],"category_scores_gemma":[0.0002096669,0.0001113081,0.0003050507,0.0004536166,0.0001469676,0.0001946102,0.0003742854,0.0003799007,0.0006205897],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003701547,"about_ca_system_score_gemma":0.0002336911,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000208573,"about_ca_topic_score_gemma":0.0003481753,"domain_scores_codex":[0.9998549,0.00001064335,0.00000994375,0.00003997392,0.00005664565,0.00002795003],"domain_scores_gemma":[0.9999021,0.00001396898,0.00004319012,0.000008438697,0.00001531029,0.00001705662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003236037,0.00002343572,0.006371146,0.0001821923,0.00003582501,0.0001887332,0.00002832566,0.0003942344,0.9765258,0.00005227608,0.0004323377,0.01544198],"study_design_scores_gemma":[0.00008025824,0.0007630604,0.1368334,0.0001048941,0.0003119548,0.004223823,0.0001620247,0.007795725,0.8249475,0.0004678671,0.02427699,0.00003253481],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876075,0.005267857,0.00319956,0.0002320091,0.00002624462,0.00005614962,0.002305106,0.0001810552,0.001124506],"genre_scores_gemma":[0.9804541,0.003490237,0.007904117,0.0002833985,0.00003006411,0.00008328784,0.006567887,0.00004761938,0.001139214],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001224279,"threshold_uncertainty_score":0.004095614,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08034417398707672,"score_gpt":0.4165432102343647,"score_spread":0.336199036247288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}