{"id":"W4409408715","doi":"10.1186/s40364-025-00769-z","title":"IL1RAP is an immunotherapeutic target for normal karyotype triple-mutated acute myeloid leukemia","year":2025,"lang":"en","type":"article","venue":"Biomarker Research","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec; Princess Margaret Cancer Centre; University of Toronto; Université de Montréal; Medical Council of Canada; Hôpital Maisonneuve-Rosemont; National Research Council Canada; Centre Hospitalier Universitaire Sainte-Justine; Institute for Research in Immunology and Cancer","funders":"Cole Foundation; Fonds de Recherche du Québec - Santé; Alliance de recherche numérique du Canada; CHU Sainte-Justine Foundation; Institut de Valorisation des Données; Canada First Research Excellence Fund; Fondation Charles-Bruneau; Université de Montréal; Stem Cell Network; Government of Canada; Génome Québec; Canadian Institutes of Health Research; Genome Canada","keywords":"NPM1; Myeloid leukemia; Medicine; Cancer research; Haematopoiesis; Myeloid; Leukemia; Antigen; Stem cell; Immunology; Karyotype; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.004196023,0.0004322029,0.000703102,0.001787477,0.0007297844,0.0002182634,0.001026327,0.0005255472,0.001630093],"category_scores_gemma":[0.0005052466,0.0003785608,0.0003353985,0.003151083,0.000700469,0.0003532076,0.0004424158,0.001239785,0.000379921],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002161358,"about_ca_system_score_gemma":0.005003039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006621905,"about_ca_topic_score_gemma":0.00002680313,"domain_scores_codex":[0.9940601,0.0006187006,0.0007189548,0.001113879,0.001483636,0.002004712],"domain_scores_gemma":[0.9955409,0.0006587343,0.00007960901,0.001580085,0.001597123,0.0005435281],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.03129305,0.0007250221,0.006710947,0.0008235177,0.003412978,0.0003776194,0.0008586717,0.000002147654,0.5176697,0.001249041,0.3346182,0.1022591],"study_design_scores_gemma":[0.02489654,0.004352963,0.0670849,0.0004110955,0.0003887616,0.0001954829,0.000929656,0.03249019,0.1839365,0.002380898,0.6819569,0.0009760719],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9114679,0.005390213,0.003768985,0.02377807,0.0009191634,0.009920033,0.0005332102,0.0006369816,0.0435855],"genre_scores_gemma":[0.8008404,0.00115005,0.008894289,0.003516606,0.0005010667,0.001570312,0.001215034,0.0003019977,0.1820103],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3473388,"threshold_uncertainty_score":0.9998666,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08034417398707672,"score_gpt":0.4165432102343647,"score_spread":0.336199036247288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}