{"id":"W4409412042","doi":"10.1084/jem.20231467","title":"Enhanced TLR7-dependent production of type I interferon by pDCs underlies pandemic chilblains","year":2025,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Dermatological and COVID-19 studies","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"National Center for Advancing Translational Sciences; National Cancer Institute; National Institutes of Health; European Academy of Dermatology and Venereology; Fondation pour la Recherche Médicale; Université Paris-Saclay; National Institute of Allergy and Infectious Diseases; Fisher Center for Alzheimer's Research Foundation; Agence Nationale de la Recherche; European Commission; Cancer Research Institute; Institut National Du Cancer; SCOR Corporate Foundation for Science; Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation; Institut National de la Santé et de la Recherche Médicale; Fondation du Souffle; National Science Foundation; European Molecular Biology Organization; Rockefeller University; Meyer Foundation; Université de Paris; Thrasher Research Fund; Fondation Leenaards; St. Giles Foundation; George Mason University; Centre Hospitalier Universitaire Vaudois; European Society for Immunodeficiencies; Schlumberger Foundation; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Howard Hughes Medical Institute","keywords":"TLR7; Immunology; Plasmacytoid dendritic cell; Interferon; Context (archaeology); TLR9; Virology; Virus; Biology; Innate immune system; Medicine; Toll-like receptor; Antigen; Dendritic cell; Immune system; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001791489,0.0002190896,0.0001580316,0.0002946258,0.000218489,0.0003004445,0.0001051218,0.000306558,0.0009426289],"category_scores_gemma":[0.0002257088,0.0001102167,0.0001420645,0.0001187566,0.0002660892,0.0001860424,0.0002564347,0.000450538,0.0001988167],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001692032,"about_ca_system_score_gemma":0.0001042535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001964271,"about_ca_topic_score_gemma":0.0001736671,"domain_scores_codex":[0.9998782,0.0000306302,0.00001252276,0.00002975076,0.00001488447,0.00003404127],"domain_scores_gemma":[0.9998759,0.00001900229,0.00004292,0.00001614701,0.00001573371,0.00003024679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0009926793,0.0001575265,0.05933527,0.0001306393,0.0000288586,0.004436773,0.0003289888,0.0001000712,0.9279681,0.0005020014,0.0002209263,0.00579811],"study_design_scores_gemma":[0.0001756828,0.002381543,0.5008528,0.00007455953,0.0001704429,0.05064844,0.002044262,0.002720869,0.4316404,0.001134561,0.008129851,0.00002663936],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998197,0.000481241,0.000351907,0.00004831819,0.000006274704,0.00001579458,0.00005944627,0.00001106212,0.0008289585],"genre_scores_gemma":[0.99953,0.0001502229,0.00009775244,0.00002299146,0.000007718601,0.000006599338,0.00004908752,0.000001353542,0.0001344449],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009426289,"threshold_uncertainty_score":0.003153384,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03009802719117442,"score_gpt":0.3479351324114061,"score_spread":0.3178371052202316,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}