{"id":"W4409412042","doi":"10.1084/jem.20231467","title":"Enhanced TLR7-dependent production of type I interferon by pDCs underlies pandemic chilblains","year":2025,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Dermatological and COVID-19 studies","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"National Center for Advancing Translational Sciences; National Cancer Institute; National Institutes of Health; European Academy of Dermatology and Venereology; Fondation pour la Recherche Médicale; Université Paris-Saclay; National Institute of Allergy and Infectious Diseases; Fisher Center for Alzheimer's Research Foundation; Agence Nationale de la Recherche; European Commission; Cancer Research Institute; Institut National Du Cancer; SCOR Corporate Foundation for Science; Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation; Institut National de la Santé et de la Recherche Médicale; Fondation du Souffle; National Science Foundation; European Molecular Biology Organization; Rockefeller University; Meyer Foundation; Université de Paris; Thrasher Research Fund; Fondation Leenaards; St. Giles Foundation; George Mason University; Centre Hospitalier Universitaire Vaudois; European Society for Immunodeficiencies; Schlumberger Foundation; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Howard Hughes Medical Institute","keywords":"TLR7; Immunology; Plasmacytoid dendritic cell; Interferon; Context (archaeology); TLR9; Virology; Virus; Biology; Innate immune system; Medicine; Toll-like receptor; Antigen; Dendritic cell; Immune system; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003472934,0.0001306003,0.0004703511,0.00009176904,0.00006983626,0.000002143306,0.000142396,0.00004498435,0.0001006357],"category_scores_gemma":[0.0002501341,0.00006332899,0.00005747826,0.0001866966,0.0003561799,0.00004677072,0.00006451861,0.0002368081,0.000003263843],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001029227,"about_ca_system_score_gemma":0.00005105816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001937329,"about_ca_topic_score_gemma":0.000002353958,"domain_scores_codex":[0.9988518,0.00007559516,0.0005238591,0.00009553316,0.0003243093,0.0001288961],"domain_scores_gemma":[0.9992641,0.0001107492,0.0002670598,0.0001530688,0.0001523106,0.00005266589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002118367,0.0003220227,0.00117635,0.00006344165,0.0002557612,0.000005748062,0.002569881,0.000002871161,0.9763321,0.0001200683,0.0156136,0.001419757],"study_design_scores_gemma":[0.002692512,0.004293772,0.002161484,0.001059103,0.0003163984,0.0002665384,0.01923701,0.000007718534,0.9673899,0.0003568829,0.00213542,0.00008328507],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9631495,0.02230926,0.0003467156,0.009657918,0.001052251,0.0002101113,5.657566e-7,0.00001472148,0.003258965],"genre_scores_gemma":[0.9949636,0.001880692,0.00002235469,0.001174752,0.0001752697,0.000002625483,0.000001605927,0.000006133984,0.001772937],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03181414,"threshold_uncertainty_score":0.2582481,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03009802719117442,"score_gpt":0.3479351324114061,"score_spread":0.3178371052202316,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}