{"id":"W4409412811","doi":"10.1158/1078-0432.ccr-24-1845","title":"A Prospective Study Consortium for the Discovery and Validation of Early Detection Markers for Ovarian Cancer – Baseline Findings for CA125","year":2025,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; School of Public Health, Imperial College London; Instituto de Salud Carlos III; World Cancer Research Fund; Medical Research Council; Centers for Disease Control and Prevention; Institut Gustave-Roussy; Deutsche Krebshilfe; Vetenskapsrådet; Ministero della Salute; Cancerfonden; Congressionally Directed Medical Research Programs; ZonMw; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; Mutuelle Générale de l'Education Nationale; U.S. Department of Defense; Associazione Italiana per la Ricerca sul Cancro; Imperial College London; Deutsches Krebsforschungszentrum; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; European Commission; Compagnia di San Paolo; Cancer Research UK; World Health Organization; Universitetet i Tromsø; NIHR Imperial Biomedical Research Centre; Centre International de Recherche sur le Cancer; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Biomarker; Prospective cohort study; Medicine; Ovarian cancer; Oncology; Cancer; Stage (stratigraphy); Internal medicine; Malignancy; Biomarker discovery; Disease; Biology; Proteomics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01234274,0.0008190579,0.0008389222,0.001355113,0.001356225,0.001870858,0.0009149571,0.0008283723,0.002305472],"category_scores_gemma":[0.02473152,0.0006126208,0.000958416,0.002971637,0.0004119268,0.0006163424,0.002316908,0.001039303,0.0006377502],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008380532,"about_ca_system_score_gemma":0.003251991,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005170389,"about_ca_topic_score_gemma":0.007829349,"domain_scores_codex":[0.9910998,0.004568803,0.0007869327,0.001792672,0.001362806,0.0003888971],"domain_scores_gemma":[0.9740222,0.003712513,0.00537505,0.007564574,0.00681958,0.002506025],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004132044,0.0002503614,0.9698384,0.0002839684,0.001329984,0.0002394686,0.0003180541,0.0002894773,0.002450785,0.001197668,0.006499455,0.0131703],"study_design_scores_gemma":[0.002345394,0.001514841,0.9708984,0.0002377602,0.001834324,0.0009721662,0.0003656527,0.001269478,0.001918021,0.0007010282,0.01788608,0.00005682871],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9252687,0.003265325,0.01623049,0.001165139,0.0004727109,0.006202627,0.03805638,0.0002310516,0.009107573],"genre_scores_gemma":[0.9423094,0.0006054888,0.01764541,0.000748977,0.0002228739,0.006109132,0.03051958,0.0001232576,0.001715832],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01234274,"threshold_uncertainty_score":0.06527543,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1495437990030987,"score_gpt":0.5181273117367589,"score_spread":0.3685835127336601,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}