{"id":"W4409413459","doi":"10.1001/jamaneurol.2025.0495","title":"Standardized Definition of Progression Independent of Relapse Activity (PIRA) in Relapsing-Remitting Multiple Sclerosis","year":2025,"lang":"en","type":"article","venue":"JAMA Neurology","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cegep de Saint Jerome; St. Michael's Hospital; Université de Montréal","funders":"","keywords":"Expanded Disability Status Scale; Medicine; Relapsing remitting; Multiple sclerosis; Cohort; McDonald criteria; Internal medicine; Pediatrics; Physical therapy; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01580313,0.0006848619,0.0008209489,0.004181315,0.0004414938,0.001147659,0.001228852,0.0006071187,0.001566552],"category_scores_gemma":[0.02947154,0.0002317067,0.001575884,0.003540092,0.00083684,0.00121077,0.001511656,0.0009851777,0.0003217882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006242507,"about_ca_system_score_gemma":0.001811907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001634244,"about_ca_topic_score_gemma":0.00238613,"domain_scores_codex":[0.9856647,0.008139053,0.002782064,0.00137869,0.001740664,0.0002948336],"domain_scores_gemma":[0.971055,0.005832925,0.01796797,0.00290023,0.001587267,0.0006566673],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0009292709,0.0001097973,0.9758833,0.0005440859,0.0009539152,0.00007641496,0.0003697419,0.000909444,0.0003440541,0.0007895489,0.001703636,0.01738691],"study_design_scores_gemma":[0.0002725316,0.001691459,0.9835421,0.0003781387,0.0006756114,0.001383165,0.0005883056,0.002319441,0.0006286991,0.001564536,0.006881769,0.00007417724],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.95929,0.004735128,0.01218706,0.0003536787,0.0002086995,0.0009279149,0.01939085,0.0001289661,0.00277773],"genre_scores_gemma":[0.9759124,0.0005216127,0.01024033,0.0001251553,0.0001217344,0.001100825,0.01164885,0.00003617848,0.0002929165],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.01580313,"threshold_uncertainty_score":0.0835759,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06546614654948855,"score_gpt":0.3319361916473563,"score_spread":0.2664700450978678,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}