{"id":"W4409423325","doi":"10.1186/s12931-025-03214-9","title":"The prevalence of pathogenic variants in the BMPR2 gene in patients with the idiopathic pulmonary arterial hypertension in the Russian population: sequencing data and meta-analysis","year":2025,"lang":"en","type":"review","venue":"Respiratory Research","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Artificial Intelligence in Medicine (Canada)","funders":"National Research University Higher School of Economics","keywords":"BMPR2; Meta-analysis; Gene; Pulmonary hypertension; ACVRL1; Genetics; Population; Medicine; Internal medicine; Biology; Cardiology; Bioinformatics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005241158,0.0008626928,0.003108414,0.002728104,0.0004442728,0.001318327,0.0007906005,0.0007862906,0.001223159],"category_scores_gemma":[0.006904845,0.0005004537,0.01234234,0.003705635,0.0003732921,0.0005218959,0.0007161754,0.0008294027,0.000122847],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003537734,"about_ca_system_score_gemma":0.0005049553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002380769,"about_ca_topic_score_gemma":0.002685351,"domain_scores_codex":[0.9968156,0.0012015,0.0006380266,0.0008378028,0.0003536971,0.0001533892],"domain_scores_gemma":[0.9947025,0.003569753,0.0007630783,0.0005341874,0.0003149296,0.0001155494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.004745611,0.00004985574,0.603066,0.009083026,0.3627178,0.0008034252,0.0002044264,0.002141307,0.002126562,0.0002214469,0.0007829083,0.01405769],"study_design_scores_gemma":[0.0003744444,0.0004240915,0.3898746,0.001022935,0.6006076,0.001365794,0.0002393607,0.002460468,0.0008368886,0.0005321204,0.002215852,0.00004570532],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.7027982,0.2887232,0.00311132,0.0005011007,0.0001902984,0.00006529293,0.003615974,0.00007037283,0.0009243212],"genre_scores_gemma":[0.9817401,0.01565441,0.000790821,0.0001151893,0.00007348329,0.00004489095,0.001442012,0.00002277724,0.0001161555],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.005241158,"threshold_uncertainty_score":0.02771819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2660253682462629,"score_gpt":0.4131058882172811,"score_spread":0.1470805199710182,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}