{"id":"W4409425448","doi":"10.1016/j.ultrasmedbio.2025.03.010","title":"Ultrasound and Microbubble Mediated Delivery of Virus-Sensitizing Drugs Improves In Vitro Oncolytic Virotherapy Against Breast Cancer Cells","year":2025,"lang":"en","type":"article","venue":"Ultrasound in Medicine & Biology","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario; Institute for Research in Immunology and Cancer","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Institute of Cancer Research; Institut Du Cancer de Montréal; Government of Canada; Frontiers Foundation; Université de Montréal; Terry Fox Foundation; Fondation du cancer du sein du Québec; Cancer Research Society","keywords":"Oncolytic virus; Virotherapy; In vitro; Medicine; Breast cancer; Cancer; Cancer research; Ultrasound; Virus; Virology; Biology; Internal medicine; Radiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002097429,0.0004137801,0.0002546706,0.0002801279,0.0001001462,0.0002759942,0.000197082,0.0004061013,0.0008971783],"category_scores_gemma":[0.0002047531,0.0001614357,0.0002754542,0.0001465866,0.0002452925,0.0002381829,0.0002030121,0.0004190475,0.0002803703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003739696,"about_ca_system_score_gemma":0.0002193588,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009260438,"about_ca_topic_score_gemma":0.001095884,"domain_scores_codex":[0.9998069,0.00003623879,0.0000176959,0.00004383355,0.00005570242,0.00003967361],"domain_scores_gemma":[0.9998858,0.00002936864,0.00004275469,0.000009296128,0.00001821552,0.00001449368],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002845559,0.00001135003,0.00003035875,0.00002154477,0.000002294222,0.00000975095,0.00001183663,0.00008629965,0.9988365,0.00002112473,0.0000126793,0.0009278317],"study_design_scores_gemma":[0.000003168,0.0001214686,0.0002938913,0.000001516717,0.000006184186,0.00002975285,0.000003522521,0.000485245,0.998599,0.000004113459,0.0004501469,0.000001938862],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866083,0.003043663,0.008727307,0.0001147268,0.00003058002,0.0000435712,0.00007472842,0.0001542563,0.001202967],"genre_scores_gemma":[0.9873855,0.00152203,0.007653644,0.00006179288,0.00001052423,0.00004829685,0.0001673903,0.0000421937,0.003108653],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009260438,"threshold_uncertainty_score":0.003001332,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005019455657060819,"score_gpt":0.2353262273311706,"score_spread":0.2303067716741098,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}